PDF(Pubmed)
Abstract：
BACKGROUND: Delivery of preventative interventions via mobile phone apps offers an effective and accessible way to address the global priority of improving the mental health of adolescents and young adults. A proven risk factor for anxiety and depression is elevated worry and rumination, also known as repetitive negative thinking (RNT).
OBJECTIVE: This was a prevention mechanism trial that aimed to investigate whether an RNT-targeting self-help mobile phone app (MyMoodCoach) reduces worry and rumination in young adults residing in the United Kingdom. A secondary objective was to test whether the app reduces symptoms of anxiety and depression and improves well-being.
METHODS: A web-based, single-blind, 2-arm parallel-group randomized controlled trial was conducted with 236 people aged between 16 and 24 years, who self-reported high levels of worry or rumination. Eligible participants were randomized to an active intervention group (usual practice, plus up to 6 weeks of using the RNT-targeting mobile app, n=119) or a waitlist control group (usual practice with no access to the app until after 6 weeks, n=117). The primary outcome was changes in worry and rumination 6 weeks after randomization. Secondary outcomes included changes in well-being and symptoms of anxiety and depression after 6 weeks and changes in all measures after 12 weeks.
RESULTS: Participants randomly allocated to use the RNT-targeting self-help app showed significantly lower levels of rumination (mean difference -2.92, 95% CI -5.57 to -0.28; P=.03; ηp2=0.02) and worry (mean difference -3.97, 95% CI -6.21 to -1.73; P<.001; ηp2=0.06) at 6-week follow-up, relative to the waitlist control. Similar differences were observed for well-being (P<.001), anxiety (P=.03), and depression (P=.04). The waitlist control group also showed improvement when given access to the app after 6 weeks. Improvements observed in the intervention group after 6 weeks of using the app were maintained at the 12-week follow-up point.
CONCLUSIONS: The MyMoodCoach app had a significant positive effect on worry and rumination, well-being, anxiety, and depression in young adults, relative to waitlist controls, providing proof-of-principle that an unguided self-help app can effectively reduce RNT. This app, therefore, has potential for the prevention of anxiety and depression although longer-term effects on incidence need to be directly evaluated.
BACKGROUND: ClinicalTrials.gov NCT04950257; https://www.clinicaltrials.gov/ct2/show/NCT04950257.
UNASSIGNED: RR2-10.1186/s12888-021-03536-0.
OBJECTIVE: This was a prevention mechanism trial that aimed to investigate whether an RNT-targeting self-help mobile phone app (MyMoodCoach) reduces worry and rumination in young adults residing in the United Kingdom. A secondary objective was to test whether the app reduces symptoms of anxiety and depression and improves well-being.
METHODS: A web-based, single-blind, 2-arm parallel-group randomized controlled trial was conducted with 236 people aged between 16 and 24 years, who self-reported high levels of worry or rumination. Eligible participants were randomized to an active intervention group (usual practice, plus up to 6 weeks of using the RNT-targeting mobile app, n=119) or a waitlist control group (usual practice with no access to the app until after 6 weeks, n=117). The primary outcome was changes in worry and rumination 6 weeks after randomization. Secondary outcomes included changes in well-being and symptoms of anxiety and depression after 6 weeks and changes in all measures after 12 weeks.
RESULTS: Participants randomly allocated to use the RNT-targeting self-help app showed significantly lower levels of rumination (mean difference -2.92, 95% CI -5.57 to -0.28; P=.03; ηp2=0.02) and worry (mean difference -3.97, 95% CI -6.21 to -1.73; P<.001; ηp2=0.06) at 6-week follow-up, relative to the waitlist control. Similar differences were observed for well-being (P<.001), anxiety (P=.03), and depression (P=.04). The waitlist control group also showed improvement when given access to the app after 6 weeks. Improvements observed in the intervention group after 6 weeks of using the app were maintained at the 12-week follow-up point.
CONCLUSIONS: The MyMoodCoach app had a significant positive effect on worry and rumination, well-being, anxiety, and depression in young adults, relative to waitlist controls, providing proof-of-principle that an unguided self-help app can effectively reduce RNT. This app, therefore, has potential for the prevention of anxiety and depression although longer-term effects on incidence need to be directly evaluated.
BACKGROUND: ClinicalTrials.gov NCT04950257; https://www.clinicaltrials.gov/ct2/show/NCT04950257.
UNASSIGNED: RR2-10.1186/s12888-021-03536-0.
摘要：
背景：通过手机应用程序提供预防性干预措施提供了一种有效且可访问的方式来解决改善青少年和年轻人心理健康的全球优先事项。焦虑和抑郁的一个被证明的风险因素是增加的担忧和沉思，也被称为重复消极思维（RNT）。
目的：这是一项预防机制试验，旨在调查针对RNT的自助手机应用程序（MyMoodCoach）是否可以减少居住在英国的年轻人的担忧和沉思。第二个目标是测试该应用程序是否可以减轻焦虑和抑郁症状并改善幸福感。
方法：基于Web的，单盲,对236名年龄在16至24岁之间的人进行了双臂平行组随机对照试验，自我报告高度担忧或沉思的人。符合条件的参与者被随机分配到积极干预组(通常做法，加上长达6周的使用RNT定位移动应用程序，n=119）或waitlist控制组（通常的做法是在6周后无法访问该应用程序，n=117）。主要结果是随机分组后6周担忧和沉思的变化。次要结果包括6周后的幸福感以及焦虑和抑郁症状的变化，以及12周后所有指标的变化。
结果：随机分配使用RNT靶向自助应用程序的参与者在6周的随访中表现出明显较低的沉思水平（平均差异-2.92，95％CI-5.57至-0.28；P=.03；ηp2=0.02）和担忧水平（平均差异-3.97，95％CI-6.21至-1.73；P<.n001;p2=0.06）相对于waitlist控件。幸福感观察到类似的差异(P<.001)，焦虑（P=0.03），和抑郁（P=.04）。等待列表对照组在6周后访问应用程序时也显示出改善。在使用该应用程序6周后，干预组观察到的改善在12周的随访点保持不变。
结论：MyMoodCoach应用程序对担忧和沉思有显著的积极作用，幸福,焦虑,年轻人的抑郁症，相对于waitlist控件，提供无指导的自助应用程序可以有效降低RNT的原理证明。这个app,因此,尽管需要直接评估对发病率的长期影响，但仍有预防焦虑和抑郁的潜力。
背景：ClinicalTrials.govNCT04950257;https://www.clinicaltrials.gov/ct2/show/NCT04950257.
■RR2-10.1186/s12888-021-03536-0。
目的：这是一项预防机制试验，旨在调查针对RNT的自助手机应用程序（MyMoodCoach）是否可以减少居住在英国的年轻人的担忧和沉思。第二个目标是测试该应用程序是否可以减轻焦虑和抑郁症状并改善幸福感。
方法：基于Web的，单盲,对236名年龄在16至24岁之间的人进行了双臂平行组随机对照试验，自我报告高度担忧或沉思的人。符合条件的参与者被随机分配到积极干预组(通常做法，加上长达6周的使用RNT定位移动应用程序，n=119）或waitlist控制组（通常的做法是在6周后无法访问该应用程序，n=117）。主要结果是随机分组后6周担忧和沉思的变化。次要结果包括6周后的幸福感以及焦虑和抑郁症状的变化，以及12周后所有指标的变化。
结果：随机分配使用RNT靶向自助应用程序的参与者在6周的随访中表现出明显较低的沉思水平（平均差异-2.92，95％CI-5.57至-0.28；P=.03；ηp2=0.02）和担忧水平（平均差异-3.97，95％CI-6.21至-1.73；P<.n001;p2=0.06）相对于waitlist控件。幸福感观察到类似的差异(P<.001)，焦虑（P=0.03），和抑郁（P=.04）。等待列表对照组在6周后访问应用程序时也显示出改善。在使用该应用程序6周后，干预组观察到的改善在12周的随访点保持不变。
结论：MyMoodCoach应用程序对担忧和沉思有显著的积极作用，幸福,焦虑,年轻人的抑郁症，相对于waitlist控件，提供无指导的自助应用程序可以有效降低RNT的原理证明。这个app,因此,尽管需要直接评估对发病率的长期影响，但仍有预防焦虑和抑郁的潜力。
背景：ClinicalTrials.govNCT04950257;https://www.clinicaltrials.gov/ct2/show/NCT04950257.
■RR2-10.1186/s12888-021-03536-0。
