PDF(Pubmed)
Abstract：
BACKGROUND: This study investigated the correlation between protein intake and Alzheimer\'s disease (AD)-related cognitive decline, particularly in episodic memory, among older adults without dementia. Furthermore, we assessed the moderating effect of apolipoprotein ε4 (APOE4) on this association and analyzed its influence on other cognitive functions beyond memory.
METHODS: The study involved 196 participants who underwent assessments for protein intake, cognitive performance, APOE4 genotyping, and nutritional biomarkers. Protein intake was categorized into low, medium, and high based on the consumption of dairy, legumes, eggs, meat, and fish.
RESULTS: High protein intake was significantly associated with better episodic memory and overall cognition. Moreover, a significant interaction was found between high protein intake and APOE4, indicating that APOE4 moderates the association between high protein intake level and episodic memory. Sensitivity analysis confirmed these results among participants with stable food intake.
CONCLUSIONS: Our study results demonstrated that high protein intake is associated with better episodic memory among older adults without dementia. Furthermore, the findings highlight the significant role of APOE4 status in moderating the relationship between protein consumption and episodic memory. These results suggest that dietary interventions focusing on protein intake could be beneficial for cognitive health, particularly in individuals with a genetic predisposition to AD.
METHODS: The study involved 196 participants who underwent assessments for protein intake, cognitive performance, APOE4 genotyping, and nutritional biomarkers. Protein intake was categorized into low, medium, and high based on the consumption of dairy, legumes, eggs, meat, and fish.
RESULTS: High protein intake was significantly associated with better episodic memory and overall cognition. Moreover, a significant interaction was found between high protein intake and APOE4, indicating that APOE4 moderates the association between high protein intake level and episodic memory. Sensitivity analysis confirmed these results among participants with stable food intake.
CONCLUSIONS: Our study results demonstrated that high protein intake is associated with better episodic memory among older adults without dementia. Furthermore, the findings highlight the significant role of APOE4 status in moderating the relationship between protein consumption and episodic memory. These results suggest that dietary interventions focusing on protein intake could be beneficial for cognitive health, particularly in individuals with a genetic predisposition to AD.
摘要：
背景：这项研究调查了蛋白质摄入与阿尔茨海默病（AD）相关的认知功能下降之间的相关性，尤其是在情景记忆中，在没有痴呆症的老年人中。此外，我们评估了载脂蛋白ε4(APOE4)对这种关联的调节作用,并分析了其对记忆以外的其他认知功能的影响.
方法：该研究涉及196名参与者，他们接受了蛋白质摄入量评估，认知表现，APOE4基因分型,和营养生物标志物。蛋白质摄入量被归类为低，中等,基于乳制品的消费量，豆类,鸡蛋,肉，和鱼。
结果：高蛋白摄入与更好的情景记忆和整体认知显著相关。此外，在高蛋白摄入和APOE4之间发现了显著的相互作用,表明APOE4调节了高蛋白摄入水平和情景记忆之间的关联.敏感性分析在食物摄入稳定的参与者中证实了这些结果。
结论：我们的研究结果表明，在没有痴呆的老年人中，高蛋白质摄入与更好的情景记忆相关。此外，研究结果强调了APOE4状态在调节蛋白质消耗和情景记忆之间关系方面的重要作用.这些结果表明，关注蛋白质摄入的饮食干预可能对认知健康有益。特别是在具有AD遗传易感性的个体中。
方法：该研究涉及196名参与者，他们接受了蛋白质摄入量评估，认知表现，APOE4基因分型,和营养生物标志物。蛋白质摄入量被归类为低，中等,基于乳制品的消费量，豆类,鸡蛋,肉，和鱼。
结果：高蛋白摄入与更好的情景记忆和整体认知显著相关。此外，在高蛋白摄入和APOE4之间发现了显著的相互作用,表明APOE4调节了高蛋白摄入水平和情景记忆之间的关联.敏感性分析在食物摄入稳定的参与者中证实了这些结果。
结论：我们的研究结果表明，在没有痴呆的老年人中，高蛋白质摄入与更好的情景记忆相关。此外，研究结果强调了APOE4状态在调节蛋白质消耗和情景记忆之间关系方面的重要作用.这些结果表明，关注蛋白质摄入的饮食干预可能对认知健康有益。特别是在具有AD遗传易感性的个体中。
