Emotional events are often remembered better than neutral ones; however, emotion can also spill over and affect our memory for neutral experiences that precede an emotional event. Theories suggest that emotion can retroactively enhance memory for preceding neutral events that are considered high-priority while impairing memory for events deemed low-priority. However, the impact of conceptual relationships (i.e., semantic connections) between preceding neutral information and emotional events on memory for the preceding information has received little attention. This study investigated the influence of conceptual relatedness on the retroactive effects of emotion on memory. Participants sequentially encoded pairs of images that were high or low in conceptual relatedness, each comprising a neutral object followed by either a negative or neutral image. Participants returned the next day for a recognition memory assessment. The results indicated an interactive effect of emotion and conceptual relatedness on memory: In a \"discovery\" sample, memory was poorer for images preceding conceptually unrelated negative (vs. neutral) images, while the opposite pattern was seen for conceptually related images. In a \"replication\" sample, these effects were partially replicated, with the former impairment effect statistically observed but not the latter augmentation effect. Hence, conceptual relatedness affects how negative emotion influences memory.

UNASSIGNED: Aging is associated with declines in theory of mind - the ability to infer the mental states of others. We examined whether priming theory of mind mindsets actively (Study 1) and passively (Study 2) improved older adults\' performance.
UNASSIGNED: Across two studies, participants completed a novel question-and-answer theory of mind task using the television show Nathan for You® in a mindset or no mindset condition. In Study 1, participants (N = 324, 18-84 years) completed a similar task related to a different show prior to the Nathan for You task (active mindset). In Study 2, young (N = 235; MAge = 20.47) and older (N = 193, MAge = 74.48) adults made continuous ratings of awkwardness of different episodes of Nathan for You before completing the question-and-answer task (passive mindset). We also measured executive function and episodic memory. In both studies, the same tasks were performed in reverse order for the control conditions (no mindset).
UNASSIGNED: Mindsets were associated with small-to-medium increases in theory of mind performance. Cognitive ability did not explain these improvements.
UNASSIGNED: These findings suggest that theory of mind performance can be improved through motivation (e.g. mindsets); cognitive function (e.g. ability) does not moderate this relationship.

Entrainment emerges when oscillatory movements synchronize with environmental stimuli processing. The purpose of this experiment was to assess how cognitive-motor entrainment during a dual-task would influence the quality of gait and affect episodic long-term memory. Twenty-one participants (22.56 y/o; 64% F) walked at preferred paces while listening to 40-item word lists. In separate sessions, unique word lists were presented predictably on every fourth stride, unpredictably related to stepping, or predictably while standing. Memory tests administered 24-hr after encoding revealed that predictable word presentation led to better free-recall performance than unpredicted (p = .044); recognition memory was not impacted. Gait phase parameters during the predicted condition were more stable than the unpredicted condition or baseline assessments. Cognitive-motor entrainment may alleviate dual-task costs and enhance memory retention.

Episodic memory is organized in both spatial and temporal contexts. The hippocampus is crucial for episodic memory and has been demonstrated to encode spatial and temporal information. However, how the representations of space and time interact in the hippocampal memory system is still unclear. Here, we recorded the activity of hippocampal CA1 neurons in mice in a variety of one-dimensional navigation tasks while systematically varying the speed of the animals. For all tasks, we found neurons simultaneously represented space and elapsed time. There was a negative correlation between the preferred space and lap duration, e.g., the preferred spatial position shifted more toward the origin when the lap duration became longer. A similar relationship between the preferred time and traveled distance was also observed. The results strongly suggest a competitive and integrated representation of space-time by single hippocampal neurons, which may provide the neural basis for spatiotemporal contexts.

Autonoetic consciousness is the awareness that an event we remember is one that we ourselves experienced. It is a defining feature of our subjective experience of remembering and imagining future events. Given its subjective nature, there is ongoing debate about how to measure it. Our goal was to develop a framework to identify cognitive markers of autonoetic consciousness. Across two studies (N = 342) we asked young, healthy participants to provide written descriptions of two autobiographical memories, two plausible future events, and an experimentally encoded video. Participants then rated their subjective experience during remembering and imagining. Exploratory Factor Analysis of this data uncovered the latent variables underlying autonoetic consciousness across these different events. In contrast to work that emphasizes the distinction between Remember and Know as being key to autonoetic consciousness, Re-experiencing, and Pre-experiencing for future events, were consistently identified as core markers of autonoetic consciousness. This was alongside Mental Time Travel in all types of memory events, but not for imagining the future. In addition, our factor analysis allows us to demonstrate directly - for the first time - the features of mental imagery associated with the sense of autonoetic consciousness in autobiographical memory; vivid, visual imagery from a first-person perspective. Finally, with regression analysis, the emergent factor structure of autonoetic consciousness was able to predict the richness of autobiographical memory texts, but not of episodic recall of the encoded video. This work provides a novel way to assess autonoetic consciousness, illustrates how autonoetic consciousness manifests differently in memory and imagination and defines the mental representations intrinsic to this process.

Aging causes changes in episodic memory. While the ability to remember the general idea or gist of past episodes is relatively preserved from the effects of aging, the ability to remember the verbatim details of these episodes declines. The aim of the present study was to examine whether age-related differences in the quality of episodic representations could be reduced by manipulations of information encoding. Two experiments were conducted with younger adults (NExp.1 = 32, NExp.2 = 31, 18-27 years old) and older adults (NExp.1 = 31, NExp.2 = 30, 54-81 years old) in which either the retrieval of gist representations of studied items was facilitated by presenting items that could be grouped within the same category (Exp. 1) or the retrieval of verbatim details of studied items was facilitated by presenting the same items repeatedly (Exp. 2). Both manipulations proved effective in increasing retrieval of either gist or verbatim representations in a recognition task in younger and older adults. Increasing gist retrieval improved correct recognition performance for both younger and older adults but also led the latter to make more recognition errors. Increasing verbatim retrieval improved correct recognition performance for both younger and older adults, and the gain was greater for older adults. These findings support the notion that age-related changes in episodic memory can be explained by changes in the specificity of representations and suggest that simple encoding manipulations could improve episodic memory in older adults.

Episodic memory, the ability to recall specific events and experiences, is a cornerstone of human cognition with profound clinical implications. While animal studies have provided valuable insights into the neuronal underpinnings of episodic memory, research has largely relied on a limited subset of tasks that model only some aspects of episodic memory. In this narrative review, we provide an overview of rodent episodic-like memory tasks that expand the methodological repertoire and diversify the approaches used in episodic-like memory research. These tasks assess various aspects of human episodic memory, such as integrated what-where-when or what-where memory, source memory, free recall, temporal binding, and threshold retrieval dynamics. We review each task\'s general principle and consider whether alternative non-episodic mechanisms can account for the observed behavior. While our list of tasks is not exhaustive, we hope it will guide researchers in selecting models that align with their specific research objectives, leading to novel advancements and a more comprehensive understanding of mechanisms underlying specific aspects of episodic memory.

OBJECTIVE: This study aimed to examine longitudinal associations of workplace effort and reward with changes in cognitive function among United States workers.
METHODS: Data from the national, population-based Midlife in the United States (MIDUS) study with a 9-year follow-up were used. Validated workplace effort and reward scales were measured at baseline, and cognitive outcomes (including composite cognition, episodic memory, and executive functioning) were measured with the Brief Test of Adult Cognition by Telephone (BTACT) at baseline and follow-up. Multivariable linear regression analyses based on generalized estimating equations (GEE) examined the longitudinal associations under study.
RESULTS: Among this worker sample of 1,399, after accounting for demographics, socioeconomics, lifestyle behaviors, health conditions, and job control, high reward at baseline was associated with increased composite cognition (regression coefficient: 0.118 [95% CI: 0.049, 0.187]), episodic memory (0.106 [0.024, 0.188]), and executive functioning (0.123 [0.055, 0.191]) during follow-up. The joint exposure of \'high effort and high reward\' was also associated with increased composite cognition (0.130 [0.030, 0.231]), episodic memory (0.131 [0.012, 0.250]), and executive functioning (0.117 [0.017, 0.216]), while the combination of \'low effort and high reward\' was associated with increased composite cognition (0.106 [0.009, 0.204]) and executive functioning (0.139 [0.042, 0.235]).
CONCLUSIONS: Findings suggest that workplace high reward is related to improved cognitive scores among United States workers. Future research should investigate larger cohorts over longer timespans and expand into disease outcomes such as dementia. If these findings emerge as causal, relevant workplace rewards to promote worker cognitive health should be considered.

The retrosplenial cortex (RSC) is a key component of the brain\'s memory systems, with anatomical connections to the hippocampus, anterior thalamus, and entorhinal cortex. This circuit has been implicated in episodic memory and many of these structures have been shown to encode temporal information, which is critical for episodic memory. For example, hippocampal time cells reliably fire during specific segments of time during a delay period. Although RSC lesions are known to disrupt temporal memory, time cells have not been observed there. In this study, we reanalyzed archival RSC neuronal firing data during the intertrial delay period from two previous experiments involving different behavioral tasks, a blocked alternation task and a cued T-maze task. For the blocked alternation task, rats were required to approach the east or west arm of a plus maze for reward during different blocks of trials. Because the reward locations were not cued, the rat had to remember the goal location for each trial. In the cued T-maze task, the reward location was explicitly cued with a light and the rats simply had to approach the light for reward, so there was no requirement to hold a memory during the intertrial delay. Time cells were prevalent in the blocked alternation task, and most time cells clearly differentiated the east and west trials. We also found that RSC neurons could exhibit off-response time fields, periods of reliably inhibited firing. Time cells were also observed in the cued T-maze, but they were less prevalent and they did not differentiate left and right trials as well as in the blocked alternation task, suggesting that RSC time cells are sensitive to the memory demands of the task. These results suggest that temporal coding is a prominent feature of RSC firing patterns, consistent with an RSC role in episodic memory.

BACKGROUND: The role of information processing speed (IPS) on relationships between episodic memory (EM) and central remodeling features in amnestic mild cognitive impairment (aMCI) was investigated.
METHODS: Neuropsychological evaluations and multimodal magnetic resonance imaging were performed on 48 patients diagnosed with aMCI and 50 healthy controls (HC). Moderation models explored the moderating effect of IPS on associations between EM and imaging features at single-region, connectivity, and network levels.
RESULTS: IPS significantly enhanced the positive correlations between recall and cortical thickness of left inferior temporal gyrus. IPS also notably amplified negative correlations between recognition and functional connectivity (FC) of left inferior parietal lobe and right occipital, as well as between recall/recognition and nodal clustering coefficient of left anterior cingulate cortex.
CONCLUSIONS: IPS functioned as a moderator of associations between recall and neuroimaging metrics at the \"single region-connectivity-network\" level, providing new insights for cognitive rehabilitation in aMCI patients.
CONCLUSIONS: aMCI patients exhibited brain functional and structural remodeling alterations. IPS moderated relations between episodic memory and brain remodeling metrics. Therapy targeted at IPS can be considered for improving episodic memory in aMCI.