PDF(Pubmed)
Abstract：
BACKGROUND: Migraine, a widespread neurological condition, substantially affects the quality of life, particularly for adolescents and young adults. While its impact is significant, there remains a paucity of comprehensive global research on the burden of migraine in younger demographics. Our study sought to elucidate the global prevalence, incidence, and disability-adjusted life-years (DALYs) associated with migraine in the 15-39 age group from 1990 to 2021, utilizing data from the Global Burden of Disease (GBD) 2021 study.
METHODS: Our comprehensive study analyzed migraine data from the GBD 2021 report, examining the prevalence, incidence, and DALYs across 204 countries and territories over a 32-year span. We stratified the information by age, sex, year, geographical region, and Socio-demographic Index (SDI). To evaluate temporal trends in these metrics, we employed the estimated annual percentage change (EAPC) calculation.
RESULTS: Between 1990 and 2021, the worldwide prevalence of migraine among 15-39 year-olds increased substantially. By 2021, an estimated 593.8 million cases were reported, representing a 39.52% rise from 425.6 million cases in 1990. Global trends showed increases in age-standardized prevalence rate, incidence rate, and DALY rate for migraine during this period. The EAPC were positive for all three metrics: 0.09 for ASPR, 0.03 for ASIR, and 0.09 for DALY rate. Regions with medium SDI reported the highest absolute numbers of prevalent cases, incident cases, and DALYs in 2021. However, high SDI regions demonstrated the most elevated rates overall. Across the globe, migraine prevalence peaked in the 35-39 age group. Notably, female rates consistently exceeded male rates across all age categories.
CONCLUSIONS: The global impact of migraine on youths and young adults has grown considerably from 1990 to 2021, revealing notable variations across SDI regions, countries, age groups, and sexes. This escalating burden necessitates targeted interventions and public health initiatives, especially in areas and populations disproportionately affected by migraine.
METHODS: Our comprehensive study analyzed migraine data from the GBD 2021 report, examining the prevalence, incidence, and DALYs across 204 countries and territories over a 32-year span. We stratified the information by age, sex, year, geographical region, and Socio-demographic Index (SDI). To evaluate temporal trends in these metrics, we employed the estimated annual percentage change (EAPC) calculation.
RESULTS: Between 1990 and 2021, the worldwide prevalence of migraine among 15-39 year-olds increased substantially. By 2021, an estimated 593.8 million cases were reported, representing a 39.52% rise from 425.6 million cases in 1990. Global trends showed increases in age-standardized prevalence rate, incidence rate, and DALY rate for migraine during this period. The EAPC were positive for all three metrics: 0.09 for ASPR, 0.03 for ASIR, and 0.09 for DALY rate. Regions with medium SDI reported the highest absolute numbers of prevalent cases, incident cases, and DALYs in 2021. However, high SDI regions demonstrated the most elevated rates overall. Across the globe, migraine prevalence peaked in the 35-39 age group. Notably, female rates consistently exceeded male rates across all age categories.
CONCLUSIONS: The global impact of migraine on youths and young adults has grown considerably from 1990 to 2021, revealing notable variations across SDI regions, countries, age groups, and sexes. This escalating burden necessitates targeted interventions and public health initiatives, especially in areas and populations disproportionately affected by migraine.
摘要：
背景：偏头痛，广泛的神经系统疾病，大大影响生活质量，特别是青少年和年轻人。虽然影响很大,关于年轻人口统计学中偏头痛负担的全球综合研究仍然很少。我们的研究试图阐明全球患病率，发病率,利用全球疾病负担（GBD）2021研究的数据，从1990年到2021年15-39岁年龄组与偏头痛相关的残疾调整寿命年（DALYs）。
方法：我们的综合研究分析了GBD2021报告中的偏头痛数据，检查患病率，发病率,在32年的时间里，有204个国家和地区的DALY。我们按年龄对信息进行分层，性别,Year,地理区域,和社会人口指数(SDI)。为了评估这些指标的时间趋势，我们采用了估计的年度百分比变化(EAPC)计算。
结果：在1990年至2021年之间，全球15-39岁人群中偏头痛的患病率大幅增加。到2021年，估计报告了5.938亿例病例，比1990年的4.256亿例增加了39.52%。全球趋势显示年龄标准化患病率增加，发病率，这一时期偏头痛的死亡率。EAPC对所有三个指标均为阳性：ASPR为0.09，0.03对于ASIR，和0.09的DALY率。SDI中等的地区报告的流行病例绝对数量最高，事件案例,和2021年的DALY。然而,高SDI地区显示出总体上最高的发病率。在全球范围内,偏头痛患病率在35-39岁年龄组达到峰值.值得注意的是,在所有年龄类别中,女性比率始终超过男性比率.
结论：从1990年到2021年，偏头痛对年轻人和年轻人的全球影响已大大增加，这表明SDI地区之间存在显着差异。国家,年龄组,和性别。这种不断升级的负担需要有针对性的干预措施和公共卫生举措，尤其是在受偏头痛影响严重的地区和人群中。
方法：我们的综合研究分析了GBD2021报告中的偏头痛数据，检查患病率，发病率,在32年的时间里，有204个国家和地区的DALY。我们按年龄对信息进行分层，性别,Year,地理区域,和社会人口指数(SDI)。为了评估这些指标的时间趋势，我们采用了估计的年度百分比变化(EAPC)计算。
结果：在1990年至2021年之间，全球15-39岁人群中偏头痛的患病率大幅增加。到2021年，估计报告了5.938亿例病例，比1990年的4.256亿例增加了39.52%。全球趋势显示年龄标准化患病率增加，发病率，这一时期偏头痛的死亡率。EAPC对所有三个指标均为阳性：ASPR为0.09，0.03对于ASIR，和0.09的DALY率。SDI中等的地区报告的流行病例绝对数量最高，事件案例,和2021年的DALY。然而,高SDI地区显示出总体上最高的发病率。在全球范围内,偏头痛患病率在35-39岁年龄组达到峰值.值得注意的是,在所有年龄类别中,女性比率始终超过男性比率.
结论：从1990年到2021年，偏头痛对年轻人和年轻人的全球影响已大大增加，这表明SDI地区之间存在显着差异。国家,年龄组,和性别。这种不断升级的负担需要有针对性的干预措施和公共卫生举措，尤其是在受偏头痛影响严重的地区和人群中。
