Abstract:
We studied the effects of visceral obesity induced by a high-calorie diet and health-improving variants of its correction on morphological characteristics of the muscle tissue in male Wistar rats. At stage I, the rats received standard (StD) or high-calorie diet (HCD) for 8 weeks. At stage II, the animals were divided into the following subgroups: no correction (StD and HCD), switching from HCD to StD (HCD/StD) and/or connection of physical activity in the form of treadmill running (StD+running, HCD+running, and HCD/StD+running) for the next 8 weeks. Diet-induced visceral obesity was shown to result in a decrease in the weight of the triceps surae muscle, fatty infiltration, intracellular edema, partial lysis of contractile elements, weak inflammatory response, and decreased muscle fiber area on cross section. Treadmill running (HCD+running) exacerbates the morphological changes, but returns muscle fiber area to normal. Correction of visceral obesity and relative normalization of muscle tissue structure was noted when switching to a standard diet (HCD/StD and HCD/StD+running).
摘要:
我们研究了高热量饮食引起的内脏肥胖及其矫正的健康改善变体对雄性Wistar大鼠肌肉组织形态特征的影响。在第一阶段,大鼠接受标准饮食(StD)或高热量饮食(HCD)8周.在第二阶段,将动物分为以下亚组:未校正(StD和HCD),从HCD切换到StD(HCD/StD)和/或以跑步机跑步形式连接体力活动(StD+跑步,HCD+正在运行,和HCD/StD+运行)在接下来的8周。饮食诱导的内脏肥胖被证明会导致肱三头肌的重量减少,脂肪渗透,细胞内水肿,收缩元素的部分裂解,弱炎症反应,横截面上的肌纤维面积减少。跑步机运行(HCD+运行)加剧了形态学的变化,但肌肉纤维面积恢复正常。当切换到标准饮食(HCD/StD和HCD/StD+跑步)时,注意到内脏肥胖的校正和肌肉组织结构的相对正常化。