Abstract：
Metal-organic frameworks (MOFs) are composite crystalline materials created through the coordination of metal ions and organic ligands. MOFs have attracted extensive attention in the biomedical field based on the advantages of internal porosity, customizable porosity, and facile surface modification. This review examines the utilization of MOFs in drug delivery systems, focusing on the research progress from the aspects of coloading drug systems, intelligent responsive carriers, biological macromolecule stabilizers, self-driving micro/nanomotors, and multifunctional living carriers. In addition, the current challenges the research faces are also discussed. The review aims to provide a reference for the further application of MOFs as advanced drug delivery systems.
摘要：
金属有机骨架（MOF）是通过金属离子和有机配体的配位产生的复合晶体材料。MOFs基于内部孔隙的优势在生物医学领域引起了广泛的关注,可定制的孔隙率，和容易的表面改性。这篇综述研究了MOFs在药物输送系统中的应用，重点从药物系统方面的研究进展，智能响应载体，生物大分子稳定剂，自动驱动微型/纳米马达，和多功能生活载体。此外,还讨论了当前研究面临的挑战。本综述旨在为MOFs作为先进药物递送系统的进一步应用提供参考。
