目的:口腔疾病,比如龋齿,牙周炎,和口腔癌,在世界范围内非常普遍。许多口腔疾病通常与细菌感染或恶性细胞增殖有关,它们通常位于表面。
方法:文章来自PubMed/Medline,Web的科学。包括并仔细评估了所有针对口腔疾病中刺激反应性物质的研究。
结果:刺激响应材料是创新材料,可以选择性地进行结构变化,并根据分子水平的变化触发药物释放,例如pH值的变化,电场,磁场,或周围环境中的光。这些变化导致材料在宏观或微观水平上的性质改变。因此,刺激响应性材料特别适用于治疗浅表部位疾病,并已在抗菌和抗癌治疗中得到广泛应用。这些特征使它们方便和有效地解决口腔疾病。
结论:这篇综述旨在总结分类,作用机制,以及刺激反应性材料在口腔疾病治疗中的应用,指出现有的局限性,并推测其临床应用前景。
结论:我们的发现可能为牙科临床医生提供口腔疾病中刺激反应物质的有用信息。
OBJECTIVE: Oral diseases, such as dental caries, periodontitis, and oral cancers, are highly prevalent worldwide. Many oral diseases are typically associated with bacterial infections or the proliferation of malignant cells, and they are usually located superficially.
METHODS: Articles were retrieved from PubMed/Medline, Web of Science. All studies focusing on stimuli-responsive materials in oral diseases were included and carefully evaluated.
RESULTS: Stimulus-responsive materials are innovative materials that selectively undergo structural changes and trigger drug release based on shifts at the molecular level, such as changes in pH, electric field, magnetic field, or light in the surrounding environment. These changes lead to alterations in the properties of the materials at the macro- or microscopic level. Consequently, stimuli-responsive materials are particularly suitable for treating superficial site diseases and have found extensive applications in antibacterial and anticancer therapies. These characteristics make them convenient and effective for addressing oral diseases.
CONCLUSIONS: This review aimed to summarize the classification, mechanism of action, and application of stimuli-responsive materials in the treatment of oral diseases, point out the existing limitations, and speculate the prospects for clinical applications.
CONCLUSIONS: Our findings may provide useful information of stimuli-responsive materials in oral diseases for dental clinicians.