癌症因其每年高死亡率而严重威胁人类健康。它在医疗保健领域引起了极大的关注,确定治疗和缓解癌症疼痛的有效策略需要紧迫性。药物递送系统(DDS)具有优异的疗效,低成本,和低毒性的靶向药物到肿瘤部位。近几十年来,基于聚(苯丙氨酸)(PPhe)和聚(3,4-二羟基-L-苯丙氨酸)(PDopa)的共聚物载体由于其良好的生物相容性而被广泛研究,生物降解性,和可控的刺激反应,这导致了具有加载和目标交付功能的DDS。在这次审查中,我们介绍了PPhe和PDopa的合成,重点介绍最新建议的合成路线,并比较PPhe和PDopa之间的药物递送差异。随后,我们总结了PPhe和PDopa在纳米级靶向DDS中的各种应用,提供基于使用这两种材料的不同刺激响应载体的药物释放行为的综合分析。最后,我们讨论了基于多肽的DDS在癌症治疗领域的挑战和前景,旨在促进其进一步发展,以满足日益增长的治疗需求。
Cancer is a serious threat to human health because of its high annual mortality rate. It has attracted significant attention in healthcare, and identifying effective strategies for the treatment and relief of cancer pain requires urgency. Drug delivery systems (DDSs) offer the advantages of excellent efficacy, low cost, and low toxicity for targeting drugs to tumor sites. In recent decades, copolymer carriers based on poly(phenylalanine) (PPhe) and poly(3,4-dihydroxy-L-phenylalanine) (PDopa) have been extensively investigated owing to their good biocompatibility, biodegradability, and controllable stimulus responsiveness, which have resulted in DDSs with loading and targeted delivery capabilities. In this review, we introduce the synthesis of PPhe and PDopa, highlighting the latest proposed synthetic routes and comparing the differences in drug delivery between PPhe and PDopa. Subsequently, we summarize the various applications of PPhe and PDopa in nanoscale-targeted DDSs, providing a comprehensive analysis of the drug release behavior based on different stimulus-responsive carriers using these two materials. In the end, we discuss the challenges and prospects of polypeptide-based DDSs in the field of cancer therapy, aiming to promote their further development to meet the growing demands for treatment.