Abstract：
RNA modifications play a crucial role in cancer development, profoundly influencing various stages of the RNA lifecycle. These stages encompass nuclear processing, nuclear export, splicing, and translation in the cytoplasm. Among RNA modifications, RNA ac4C modification, also known as N4-acetylcytidine, stands out for its unique role in acetylation processes. Specific proteins regulate RNA ac4C modification, maintaining the dynamic and reversible nature of these changes. This review explores the molecular mechanisms and biological functions of RNA ac4C modification. It examines the intricate ways in which RNA ac4C modification influences the pathogenesis and progression of cancer. Additionally, the review provides an integrated overview of the current methodologies for detecting RNA ac4C modification. Exploring the potential applications of manipulating this modification suggests avenues for novel therapeutic strategies, potentially leading to more effective cancer treatments in the future.
摘要：
RNA修饰在癌症发展中起着至关重要的作用。深刻影响RNA生命周期的各个阶段。这些阶段包括核加工，核出口,拼接,和细胞质中的翻译。在RNA修饰中，ac4CRNA修饰，也称为N4-乙酰胞苷，突出了它在乙酰化过程中的独特作用。特定的蛋白质调节ac4CRNA修饰，保持这些变化的动态和可逆性质。本文就ac4CRNA修饰的分子机制和生物学功能进行综述。它研究了ac4CRNA修饰影响癌症发病机理和进展的复杂方式。此外,这篇综述提供了当前检测ac4CRNA修饰的方法的综合概述.探索操纵这种修饰的潜在应用，为新的治疗策略提供了途径。有可能导致未来更有效的癌症治疗。
