{Reference Type}: Journal Article
{Title}: RNA ac4C modification in cancer: Unraveling multifaceted roles and promising therapeutic horizons.
{Author}: Ouyang W;Huang Z;Wan K;Nie T;Chen H;Yao H;
{Journal}: Cancer Lett
{Volume}: 601
{Issue}: 0
{Year}: 2024 Oct 1
{Factor}: 9.756
{DOI}: 10.1016/j.canlet.2024.217159
{Abstract}: RNA modifications play a crucial role in cancer development, profoundly influencing various stages of the RNA lifecycle. These stages encompass nuclear processing, nuclear export, splicing, and translation in the cytoplasm. Among RNA modifications, RNA ac4C modification, also known as N4-acetylcytidine, stands out for its unique role in acetylation processes. Specific proteins regulate RNA ac4C modification, maintaining the dynamic and reversible nature of these changes. This review explores the molecular mechanisms and biological functions of RNA ac4C modification. It examines the intricate ways in which RNA ac4C modification influences the pathogenesis and progression of cancer. Additionally, the review provides an integrated overview of the current methodologies for detecting RNA ac4C modification. Exploring the potential applications of manipulating this modification suggests avenues for novel therapeutic strategies, potentially leading to more effective cancer treatments in the future.