PDF(Pubmed)
Abstract：
UNASSIGNED: In the treatment of early stage laryngeal cancers, surgery (transoral laryngeal surgery (TOLS), open partial laryngeal surgery (OPLS) and radiotherapy (RT) are used.
UNASSIGNED: Compare the oncological results of patients with early stage laryngeal squamous cell carcinoma (LSCC) treated with TOLS or RT.
UNASSIGNED: Retrospective.
UNASSIGNED: Tertiary training and research hospital.
UNASSIGNED: The participants were divided into patients who underwent TOLS and RT treatment. The groups were compared with each other in terms of local recurrence, regional recurrence, distant metastasis, 3 and 5-year overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS) and laryngectomy-free survival rates (LFS).
UNASSIGNED: The effects of TOLS and RT treatment on local control, regional control, OS, DFS, DDS and LFS in early stage laryngeal cancers.
UNASSIGNED: 261.
UNASSIGNED: The mean follow-up time was 48 (26) months. There were 186 patients who underwent TOLS and 75 patients who underwent RT treatment. Gender, cigarette/alcohol consumption, tumor localization, anterior commissure involvement, tumor grades, recurrence rates and recurrence localizations of the groups were similar. The 5-year overall, disease specific, disease free and laryngectomy-free survival rates were 85.9%, 88%, 79.4%, 96.3% in the TOLS group and 74.3%, 76.7%, 72.3%, 85.2% in the RT group (P=.034, .065, .269, .060, respectively).
UNASSIGNED: TOLS had equal and good oncological outcomes on OS and DFS compared to RT. Anterior commissure involvement was statistically significant independent prognostic risk factor for DFS in both groups. The 5-year OS rate was greater in the TOLS groups (P=.034).
UNASSIGNED: Retrospective, but to the best our knowledge, this is the first study in Turkey with a high patient volume and a long follow-up time.
UNASSIGNED: Compare the oncological results of patients with early stage laryngeal squamous cell carcinoma (LSCC) treated with TOLS or RT.
UNASSIGNED: Retrospective.
UNASSIGNED: Tertiary training and research hospital.
UNASSIGNED: The participants were divided into patients who underwent TOLS and RT treatment. The groups were compared with each other in terms of local recurrence, regional recurrence, distant metastasis, 3 and 5-year overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS) and laryngectomy-free survival rates (LFS).
UNASSIGNED: The effects of TOLS and RT treatment on local control, regional control, OS, DFS, DDS and LFS in early stage laryngeal cancers.
UNASSIGNED: 261.
UNASSIGNED: The mean follow-up time was 48 (26) months. There were 186 patients who underwent TOLS and 75 patients who underwent RT treatment. Gender, cigarette/alcohol consumption, tumor localization, anterior commissure involvement, tumor grades, recurrence rates and recurrence localizations of the groups were similar. The 5-year overall, disease specific, disease free and laryngectomy-free survival rates were 85.9%, 88%, 79.4%, 96.3% in the TOLS group and 74.3%, 76.7%, 72.3%, 85.2% in the RT group (P=.034, .065, .269, .060, respectively).
UNASSIGNED: TOLS had equal and good oncological outcomes on OS and DFS compared to RT. Anterior commissure involvement was statistically significant independent prognostic risk factor for DFS in both groups. The 5-year OS rate was greater in the TOLS groups (P=.034).
UNASSIGNED: Retrospective, but to the best our knowledge, this is the first study in Turkey with a high patient volume and a long follow-up time.
摘要：
■在早期喉癌的治疗中，手术（经口喉部手术（TOLS），开放部分喉手术（OPLS）和放射治疗（RT）。
■比较TOLS或RT治疗的早期喉鳞状细胞癌（LSCC）患者的肿瘤学结果。
■回顾性研究。
■三级培训和研究医院。
■参与者被分为接受TOLS和RT治疗的患者。两组在局部复发方面进行比较,区域性复发，远处转移,3年和5年总生存期（OS），无病生存率（DFS），疾病特异性生存率（DSS）和无喉切除术生存率（LFS）。
■TOLS和RT治疗对局部控制的影响，区域控制,操作系统,DFS,早期喉癌的DDS和LFS。
■261。
■平均随访时间为48（26）个月。有186例患者接受了TOLS治疗，75例患者接受了RT治疗。性别,香烟/酒精消费，肿瘤定位，前连合受累,肿瘤等级,两组的复发率和复发部位相似.5年总体来说,疾病特异性,无病和无喉切除术生存率为85.9%，88%,79.4%,TOLS组的96.3%和74.3%，76.7%,72.3%,RT组为85.2%（分别为P=.034、.065、.269、.060）。
■与RT相比，TOLS在OS和DFS上的肿瘤学结果相同且良好。前连合受累是两组DFS的统计学显著独立预后危险因素。TOLS组的5年OS率更高（P=.034）。
■回顾性，但就我们所知,这是土耳其首例患者量大,随访时间长的研究.
■比较TOLS或RT治疗的早期喉鳞状细胞癌（LSCC）患者的肿瘤学结果。
■回顾性研究。
■三级培训和研究医院。
■参与者被分为接受TOLS和RT治疗的患者。两组在局部复发方面进行比较,区域性复发，远处转移,3年和5年总生存期（OS），无病生存率（DFS），疾病特异性生存率（DSS）和无喉切除术生存率（LFS）。
■TOLS和RT治疗对局部控制的影响，区域控制,操作系统,DFS,早期喉癌的DDS和LFS。
■261。
■平均随访时间为48（26）个月。有186例患者接受了TOLS治疗，75例患者接受了RT治疗。性别,香烟/酒精消费，肿瘤定位，前连合受累,肿瘤等级,两组的复发率和复发部位相似.5年总体来说,疾病特异性,无病和无喉切除术生存率为85.9%，88%,79.4%,TOLS组的96.3%和74.3%，76.7%,72.3%,RT组为85.2%（分别为P=.034、.065、.269、.060）。
■与RT相比，TOLS在OS和DFS上的肿瘤学结果相同且良好。前连合受累是两组DFS的统计学显著独立预后危险因素。TOLS组的5年OS率更高（P=.034）。
■回顾性，但就我们所知,这是土耳其首例患者量大,随访时间长的研究.
