{Reference Type}: Journal Article
{Title}: Comparisons of the oncological results of transoral laser surgery and radiotherapy for early stage laryngeal squamous cell cancer: single-center long-term results.
{Author}: Doluoglu S;Bayir O;Ocal B;Tatar EC;Korkmaz MH;Saylam G;
{Journal}: Ann Saudi Med
{Volume}: 44
{Issue}: 4
{Year}: 2024 Jul-Aug
{Factor}: 1.707
{DOI}: 10.5144/0256-4947.2024.213
{Abstract}: <B>UNASSIGNED: </B>In the treatment of early stage laryngeal cancers, surgery (transoral laryngeal surgery (TOLS), open partial laryngeal surgery (OPLS) and radiotherapy (RT) are used.<BR><B>UNASSIGNED: </B>Compare the oncological results of patients with early stage laryngeal squamous cell carcinoma (LSCC) treated with TOLS or RT.<BR><B>UNASSIGNED: </B>Retrospective.<BR><B>UNASSIGNED: </B>Tertiary training and research hospital.<BR><B>UNASSIGNED: </B>The participants were divided into patients who underwent TOLS and RT treatment. The groups were compared with each other in terms of local recurrence, regional recurrence, distant metastasis, 3 and 5-year overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS) and laryngectomy-free survival rates (LFS).<BR><B>UNASSIGNED: </B>The effects of TOLS and RT treatment on local control, regional control, OS, DFS, DDS and LFS in early stage laryngeal cancers.<BR><B>UNASSIGNED: </B>261.<BR><B>UNASSIGNED: </B>The mean follow-up time was 48 (26) months. There were 186 patients who underwent TOLS and 75 patients who underwent RT treatment. Gender, cigarette/alcohol consumption, tumor localization, anterior commissure involvement, tumor grades, recurrence rates and recurrence localizations of the groups were similar. The 5-year overall, disease specific, disease free and laryngectomy-free survival rates were 85.9%, 88%, 79.4%, 96.3% in the TOLS group and 74.3%, 76.7%, 72.3%, 85.2% in the RT group (P=.034, .065, .269, .060, respectively).<BR><B>UNASSIGNED: </B>TOLS had equal and good oncological outcomes on OS and DFS compared to RT. Anterior commissure involvement was statistically significant independent prognostic risk factor for DFS in both groups. The 5-year OS rate was greater in the TOLS groups (P=.034).<BR><B>UNASSIGNED: </B>Retrospective, but to the best our knowledge, this is the first study in Turkey with a high patient volume and a long follow-up time.