PDF(Pubmed)
Abstract：
Acute coronavirus disease 2019 (COVID-19) is paralleled by a rise in the peripheral levels of neurofilament light chain (NfL), suggesting early nervous system damage. In a cohort of 103 COVID-19 patients, we studied the relationship between the NfL and peripheral inflammatory markers. We found that the NfL levels are significantly predicted by a panel of circulating cytokines/chemokines, including CRP, IL-4, IL-8, IL-9, Eotaxin, and MIP-1ß, which are highly up-regulated during COVID-19 and are associated with clinical outcomes. Our findings show that peripheral cytokines influence the plasma levels of the NfL, suggesting a potential role of the NfL as a marker of neuronal damage associated with COVID-19 inflammation.
摘要：
急性冠状病毒病2019（COVID-19）与神经丝轻链（NfL）的外周水平升高平行，提示早期神经系统受损.在103名COVID-19患者的队列中，我们研究了NfL与外周炎症标志物之间的关系。我们发现一组循环细胞因子/趋化因子显著预测了NfL水平，包括CRP,IL-4，IL-8，IL-9，Eotaxin，和MIP-1β，在COVID-19期间高度上调，并与临床结局相关。我们的研究结果表明，外周细胞因子影响NfL的血浆水平，提示NfL作为与COVID-19炎症相关的神经元损伤标志物的潜在作用。
