%0 Journal Article
%T Inflammatory Markers Predict Blood Neurofilament Light Chain Levels in Acute COVID-19 Patients.
%A De Lorenzo R
%A Loré NI
%A Finardi A
%A Mandelli A
%A Calesella F
%A Palladini M
%A Cirillo DM
%A Tresoldi C
%A Ciceri F
%A Rovere-Querini P
%A Manfredi AA
%A Mazza MG
%A Benedetti F
%A Furlan R
%J Int J Mol Sci
%V 25
%N 15
%D 2024 Jul 29
%M 39125829
%F 6.208
%R 10.3390/ijms25158259
%X Acute coronavirus disease 2019 (COVID-19) is paralleled by a rise in the peripheral levels of neurofilament light chain (NfL), suggesting early nervous system damage. In a cohort of 103 COVID-19 patients, we studied the relationship between the NfL and peripheral inflammatory markers. We found that the NfL levels are significantly predicted by a panel of circulating cytokines/chemokines, including CRP, IL-4, IL-8, IL-9, Eotaxin, and MIP-1ß, which are highly up-regulated during COVID-19 and are associated with clinical outcomes. Our findings show that peripheral cytokines influence the plasma levels of the NfL, suggesting a potential role of the NfL as a marker of neuronal damage associated with COVID-19 inflammation.