{Reference Type}: Journal Article
{Title}: Inflammatory Markers Predict Blood Neurofilament Light Chain Levels in Acute COVID-19 Patients.
{Author}: De Lorenzo R;Loré NI;Finardi A;Mandelli A;Calesella F;Palladini M;Cirillo DM;Tresoldi C;Ciceri F;Rovere-Querini P;Manfredi AA;Mazza MG;Benedetti F;Furlan R;
{Journal}: Int J Mol Sci
{Volume}: 25
{Issue}: 15
{Year}: 2024 Jul 29
{Factor}: 6.208
{DOI}: 10.3390/ijms25158259
{Abstract}: Acute coronavirus disease 2019 (COVID-19) is paralleled by a rise in the peripheral levels of neurofilament light chain (NfL), suggesting early nervous system damage. In a cohort of 103 COVID-19 patients, we studied the relationship between the NfL and peripheral inflammatory markers. We found that the NfL levels are significantly predicted by a panel of circulating cytokines/chemokines, including CRP, IL-4, IL-8, IL-9, Eotaxin, and MIP-1ß, which are highly up-regulated during COVID-19 and are associated with clinical outcomes. Our findings show that peripheral cytokines influence the plasma levels of the NfL, suggesting a potential role of the NfL as a marker of neuronal damage associated with COVID-19 inflammation.