PDF(Pubmed)
Abstract：
Oxidative stress is a major source of ROS-mediated damage to macromolecules, tissues, and the whole body. It is an important marker in the severe picture of pathological conditions. The discovery of free radicals in biological systems gives a \"start\" to studying various pathological processes related to the development and progression of many diseases. From this moment on, the enrichment of knowledge about the participation of free radicals and free-radical processes in the pathogenesis of cardiovascular, neurodegenerative, and endocrine diseases, inflammatory conditions, and infections, including COVID-19, is increasing exponentially. Excessive inflammatory responses and abnormal reactive oxygen species (ROS) levels may disrupt mitochondrial dynamics, increasing the risk of cell damage. In addition, low serum albumin levels and changes in the normal physiological balance between reduced and oxidized albumin can be a serious prerequisite for impaired antioxidant capacity of the body, worsening the condition in patients. This review presents the interrelationship between oxidative stress, inflammation, and low albumin levels, which are hallmarks of COVID-19.
摘要：
氧化应激是ROS介导的大分子损伤的主要来源，组织，和整个身体。它是严重病理状况的重要标志。生物系统中自由基的发现为研究与许多疾病的发展和进展有关的各种病理过程提供了“起点”。从这一刻起,关于自由基和自由基过程参与心血管发病机理的知识的丰富，神经退行性疾病，和内分泌疾病，炎症条件，和感染，包括COVID-19，呈指数级增长。过度的炎症反应和异常的活性氧（ROS）水平可能会破坏线粒体动力学，增加细胞损伤的风险。此外,低血清白蛋白水平和还原白蛋白和氧化白蛋白之间正常生理平衡的变化可能是身体抗氧化能力受损的严重先决条件，患者病情恶化。本文综述了氧化应激之间的相互关系，炎症,白蛋白水平低,这是COVID-19的标志。
