PDF(Pubmed)
Abstract：
The functional importance of the anterior temporal lobes (ATLs) has come to prominence in two active, albeit unconnected literatures-(i) face recognition and (ii) semantic memory. To generate a unified account of the ATLs, we tested the predictions from each literature and examined the effects of bilateral versus unilateral ATL damage on face recognition, person knowledge, and semantic memory. Sixteen people with bilateral ATL atrophy from semantic dementia (SD), 17 people with unilateral ATL resection for temporal lobe epilepsy (TLE; left = 10, right = 7), and 14 controls completed tasks assessing perceptual face matching, person knowledge and general semantic memory. People with SD were impaired across all semantic tasks, including person knowledge. Despite commensurate total ATL damage, unilateral resection generated mild impairments, with minimal differences between left- and right-ATL resection. Face matching performance was largely preserved but slightly reduced in SD and right TLE. All groups displayed the familiarity effect in face matching; however, it was reduced in SD and right TLE and was aligned with the level of item-specific semantic knowledge in all participants. We propose a neurocognitive framework whereby the ATLs underpin a resilient bilateral representation system that supports semantic memory, person knowledge and face recognition.
摘要：
颞叶前叶（ATL）的功能重要性在两个活跃的，尽管没有联系的文献-(i)面部识别和(ii)语义记忆。要生成ATL的统一帐户，我们测试了每个文献的预测，并检查了双边和单边ATL损伤对人脸识别的影响，人的知识,和语义记忆。语义性痴呆（SD）导致双侧ATL萎缩的16人，17人单侧ATL切除颞叶癫痫（TLE；左=10，右=7），14个控件完成了评估感知面部匹配的任务，人的知识和一般的语义记忆。患有SD的人在所有语义任务中都受到损害，包括人的知识。尽管ATL的总损坏相应，单侧切除产生轻度损伤，左侧和右侧ATL切除术之间的差异最小。在SD和右侧TLE中，面部匹配性能得到了很大程度的保留，但略有降低。所有组都在面部匹配中显示熟悉效果；但是，它在SD和右TLE中减少,并且与所有参与者的项目特异性语义知识水平一致.我们提出了一个神经认知框架，借此ATL支持支持语义记忆的弹性双边表示系统，人的知识和面部识别。
