Abstract：
Hemorrhagic fever with renal syndrome (HFRS) and severe fever with thrombocytopenia syndrome (SFTS) are both endemic in rural areas and some characteristics are similar between HFRS and SFTS, which usually lead to misdiagnosis. In this study, we summarized and compared some characteristics of HFRS and SFTS which will provide scientific information for differential diagnosis. From 2011 to 2022, a total of 4336 HFRS cases and 737 SFTS cases were reported in Zhejiang Province. Compared to SFTS, there was a higher proportion of males among HFRS cases (72.46% [3142/4336] vs. 50.88% [375/737], p = 0.000). The median age of all 4336 HFRS cases was 49 (39, 59), while the median age of SFTS cases was 66 (57, 74). In addition, the involved counties of HFRS were more than SFTS, but the number of counties affected by SFTS increased from 2011 to 2022. The majority of SFTS cases occurred in summer (from May to July), but besides summer, HFRS cases also showed a peak in winter. Finally, our results showed that the case fatality rate of SFTS was significantly higher than that of HFRS. Although there were some similarities between HFRS and SFTS, our study found several differences between them, such as gender distribution, age distribution, and seasonal distribution, which will provide scientific information for differential diagnosis of HFRS and SFTS. Further studies should be carried out to explore the mechanism of these differences.
摘要：
肾综合征出血热（HFRS）和血小板减少综合征（SFTS）在农村地区都很流行，HFRS和SFTS之间的一些特征相似。这通常会导致误诊。在这项研究中,我们总结并比较了HFRS和SFTS的一些特征，这将为鉴别诊断提供科学信息。2011年至2022年，浙江省共报告43例HFRS和737例SFTS。与SFTS相比，HFRS病例中男性比例较高(72.46%[3142/4336]与50.88%[375/737]，p=0.000）。所有4336例HFRS病例的中位年龄为49（39，59），而SFTS病例的中位年龄为66(57,74)。此外,HFRS涉及的县比SFTS多，但从2011年到2022年，受SFTS影响的县数量有所增加。大多数SFTS病例发生在夏季（5月至7月），但除了夏天,HFRS病例也在冬季出现高峰。最后,我们的结果表明，SFTS的病死率明显高于HFRS。尽管HFRS和SFTS之间有一些相似之处，我们的研究发现了它们之间的一些差异，比如性别分布，年龄分布，和季节性分布，这将为HFRS和SFTS的鉴别诊断提供科学信息。应该进行进一步的研究来探索这些差异的机制。
