Abstract：
The repair of large bone defects poses a significant challenge in orthopedics. Polyetheretherketone (PEEK) is a promising bone substitute, while it suffers a lack of bioactivity. Although several studies have been performed to further improve the bioactivities of PEEK by various surface modifications, PEEK offering long-term, multifaceted biofunctionalities remains still desired. In this study, we introduced metal-organic frameworks (MOFs), specifically ZIF-8 loaded with celecoxib (ZIF-8(CEL)), onto the PEEK surface through dopamine adhesion. The resulting PEEK@ZIF-8(CEL) aims to achieve long-term stable release of Zn ions and CEL for enhanced bone integration. Material characterization and biological experiments confirmed the successful integration of ZIF-8(CEL) onto PEEK and its positive biomedical effects, including creating a positive bone immunological environment and promoting bone growth. This study demonstrates the potential of PEEK@ZIF-8(CEL) as a novel repair material for large bone defects, offering a promising alternative in orthopedic applications.
摘要：
大型骨缺损的修复在骨科中提出了重大挑战。聚醚醚酮(PEEK)是一种很有前途的骨替代物,虽然它缺乏生物活性。尽管已经进行了一些研究以通过各种表面改性进一步改善PEEK的生物活性。PEEK提供长期，多方面的生物功能仍然是需要的。在这项研究中,我们引入了金属有机骨架(MOFs)，特别是ZIF-8负载塞来昔布（ZIF-8（CEL）），通过多巴胺粘附到PEEK表面。所得的PEEK@ZIF-8(CEL)旨在实现Zn离子和CEL的长期稳定释放以增强骨整合。材料表征和生物学实验证实了ZIF-8（CEL）成功整合到PEEK上及其积极的生物医学效果，包括创造积极的骨骼免疫环境和促进骨骼生长。这项研究证明了PEEK@ZIF-8（CEL）作为一种新型修复材料的潜力，在骨科应用中提供了一个有前途的替代方案。
