PDF(Pubmed)
Abstract：
UNASSIGNED: This study aims to identify the rate of occult nodal metastasis (ONM), risk factors associated with ONM, and compare regional recurrence (RR), 2-year disease-free survival (DFS) in patients treated with elective neck dissection (END) versus expectant management (OBS) for primary T1-T2 gingival squamous cell carcinoma (GSCC) of the maxilla and mandible.
UNASSIGNED: A retrospective analysis was conducted and included patients from 2014 to 2021 who were treated at a tertiary referral center.
UNASSIGNED: Twenty patients underwent END and 36 were managed expectantly, with a mean follow-up period of 28 months. ONM was observed in 26% of the study cohort with 16.7% occurring in the maxilla and 36.4% in the mandible. No specific histopathologic features were predictive for ONM. No regional recurrence occurred. Local recurrence occurred in 5% and 2.8% of END and OBS groups, respectively. Two-year DFS were comparable between the END (93.8%) versus OBS (83.9%) as well as maxilla (90.9%) versus mandible (83.4%), P > 0.05.
UNASSIGNED: ONM remains variable in cT1-T2N0 GSCC with a greater incidence occurring in the mandible when compared to the maxilla, respectively. An END should be strongly considered for mandibular GSCC. Overall, END for the N0 neck has been shown to provide significant overall and disease-free survival benefits. However, further prospective randomized studies are needed to verify risk factors for ONM and validate the disease-related survival benefit of an elective neck dissection in this patient population.
UNASSIGNED: A retrospective analysis was conducted and included patients from 2014 to 2021 who were treated at a tertiary referral center.
UNASSIGNED: Twenty patients underwent END and 36 were managed expectantly, with a mean follow-up period of 28 months. ONM was observed in 26% of the study cohort with 16.7% occurring in the maxilla and 36.4% in the mandible. No specific histopathologic features were predictive for ONM. No regional recurrence occurred. Local recurrence occurred in 5% and 2.8% of END and OBS groups, respectively. Two-year DFS were comparable between the END (93.8%) versus OBS (83.9%) as well as maxilla (90.9%) versus mandible (83.4%), P > 0.05.
UNASSIGNED: ONM remains variable in cT1-T2N0 GSCC with a greater incidence occurring in the mandible when compared to the maxilla, respectively. An END should be strongly considered for mandibular GSCC. Overall, END for the N0 neck has been shown to provide significant overall and disease-free survival benefits. However, further prospective randomized studies are needed to verify risk factors for ONM and validate the disease-related survival benefit of an elective neck dissection in this patient population.
摘要：
■本研究旨在确定隐匿性淋巴结转移率（ONM），与ONM相关的危险因素，并比较区域复发(RR)，选择性颈淋巴结清扫术（END）与期待治疗（OBS）治疗上颌骨和下颌骨的原发性T1-T2牙龈鳞状细胞癌（GSCC）的2年无病生存期（DFS）。
■进行了回顾性分析，包括2014年至2021年在三级转诊中心接受治疗的患者。
■20例患者接受了END，36例患者接受了预期治疗，平均随访28个月。在26％的研究队列中观察到ONM，其中上颌骨占16.7％，下颌骨占36.4％。没有特定的组织病理学特征可预测ONM。无区域性复发。END和OBS组的局部复发发生率分别为5%和2.8%。分别。两年的DFS在END（93.8％）与OBS（83.9％）以及上颌骨（90.9％）与下颌骨（83.4％）之间具有可比性，P>0.05。
■ONM在cT1-T2N0GSCC中保持可变，与上颌骨相比，下颌骨的发病率更高，分别。下颌GSCC应强烈考虑END。总的来说,N0颈部的END已显示提供显著的总体和无病生存益处。然而,需要进一步的前瞻性随机研究来验证ONM的危险因素,并验证该患者人群中择期颈清扫术的疾病相关生存获益.
■进行了回顾性分析，包括2014年至2021年在三级转诊中心接受治疗的患者。
■20例患者接受了END，36例患者接受了预期治疗，平均随访28个月。在26％的研究队列中观察到ONM，其中上颌骨占16.7％，下颌骨占36.4％。没有特定的组织病理学特征可预测ONM。无区域性复发。END和OBS组的局部复发发生率分别为5%和2.8%。分别。两年的DFS在END（93.8％）与OBS（83.9％）以及上颌骨（90.9％）与下颌骨（83.4％）之间具有可比性，P>0.05。
■ONM在cT1-T2N0GSCC中保持可变，与上颌骨相比，下颌骨的发病率更高，分别。下颌GSCC应强烈考虑END。总的来说,N0颈部的END已显示提供显著的总体和无病生存益处。然而,需要进一步的前瞻性随机研究来验证ONM的危险因素,并验证该患者人群中择期颈清扫术的疾病相关生存获益.
