%0 Journal Article
%T Risk Factors Associated with Occult Nodal Metastasis and Outcomes for cT1-2N0 Maxillary and Mandibular gingival Carcinoma: A Retrospective Study.
%A Le JM
%A Sayre KS
%A Sesanto R
%A Seri C
%A Ying YP
%A Morlandt AB
%J J Maxillofac Oral Surg
%V 23
%N 4
%D 2024 Aug
%M 39118910
暂无%R 10.1007/s12663-023-02035-x
%X <B>UNASSIGNED: </B>This study aims to identify the rate of occult nodal metastasis (ONM), risk factors associated with ONM, and compare regional recurrence (RR), 2-year disease-free survival (DFS) in patients treated with elective neck dissection (END) versus expectant management (OBS) for primary T1-T2 gingival squamous cell carcinoma (GSCC) of the maxilla and mandible.<BR><B>UNASSIGNED: </B>A retrospective analysis was conducted and included patients from 2014 to 2021 who were treated at a tertiary referral center.<BR><B>UNASSIGNED: </B>Twenty patients underwent END and 36 were managed expectantly, with a mean follow-up period of 28 months. ONM was observed in 26% of the study cohort with 16.7% occurring in the maxilla and 36.4% in the mandible. No specific histopathologic features were predictive for ONM. No regional recurrence occurred. Local recurrence occurred in 5% and 2.8% of END and OBS groups, respectively. Two-year DFS were comparable between the END (93.8%) versus OBS (83.9%) as well as maxilla (90.9%) versus mandible (83.4%), P > 0.05.<BR><B>UNASSIGNED: </B>ONM remains variable in cT1-T2N0 GSCC with a greater incidence occurring in the mandible when compared to the maxilla, respectively. An END should be strongly considered for mandibular GSCC. Overall, END for the N0 neck has been shown to provide significant overall and disease-free survival benefits. However, further prospective randomized studies are needed to verify risk factors for ONM and validate the disease-related survival benefit of an elective neck dissection in this patient population.