PDF(Pubmed)
Abstract：
Gaining a comprehensive understanding of the role played by the oral microbiome in moderate to severe plaque psoriasis and its potential implications for disease management and development holds significant importance. With the objective of exploring correlations between the oral microbiota and severe psoriasis, this study involved 72 severe psoriasis patients and 16 healthy individuals, whose clinical manifestations and living habits were carefully recorded. Cutting-edge techniques such as 16S rRNA gene sequencing and bioinformatics analysis were employed to compare the microbial flora, investigating dynamic changes among severe plaque psoriasis patients, psoriatic arthritis patients and healthy individuals. The findings revealed noteworthy patterns including increased levels of Aggregatibacter in the psoriatic arthritis group, accompanied by a decrease in the level of Prevotella. Moreover, the enrichment o Capnocytandophaga (P = 0.009), Campylobacter (P = 0.0022), and Acetobacter (P = 0.0292) was notably more substantial in the psoriasis group compared to the control group, whereas certain bacterial species such as Bacteroides (P = 0.0049), Muribaculaceae (P = 0.0048) demonstrated decreased enrichment. Additionally, the psoriatic arthritis group exhibited significantly higher levels of Ralstonia, Bifidobacterium and Micromonospora. Based on these findings, it can be inferred that individuals with lower levels of Prevotella and higher levels of Corynebacterium may be more susceptible to psoriasis exacerbation.
摘要：
全面了解口腔微生物组在中度至重度斑块型银屑病中的作用及其对疾病管理和发展的潜在影响具有重要意义。为了探讨口腔微生物群与重度银屑病的相关性,这项研究涉及72名严重银屑病患者和16名健康个体，仔细记录其临床表现和生活习惯。采用16SrRNA基因测序和生物信息学分析等前沿技术对微生物菌群进行比较,研究严重斑块型银屑病患者的动态变化，银屑病关节炎患者和健康个体。研究结果揭示了值得注意的模式，包括银屑病关节炎组的Aggregatibacter水平升高，伴随着普雷沃氏菌水平的下降。此外，Capnocytandophaga的富集（P=0.009），弯曲杆菌（P=0.0022），和醋杆菌（P=0.0292）在银屑病组中明显高于对照组，而某些细菌物种，如拟杆菌(P=0.0049)，Muribaculaceae（P=0.0048）显示出减少的富集。此外,银屑病关节炎组表现出明显更高水平的Ralstonia，双歧杆菌和小单孢菌。基于这些发现,可以推断,普雷沃氏菌水平较低,棒状杆菌水平较高的个体可能更容易发生银屑病加重.
