PDF(Pubmed)
Abstract：
Without intervention, cardiac arrhythmias pose a risk of fatality. However, timely intervention can be challenging in environments where transporting a large, heavy defibrillator is impractical, or emergency surgery to implant cardiac stimulation devices is not feasible. Here, we introduce an injectable cardiac stimulator, a syringe loaded with a nanoparticle solution comprising a conductive polymer and a monomer that, upon injection, forms a conductive structure around the heart for cardiac stimulation. Following treatment, the electrode is cleared from the body, eliminating the need for surgical extraction. The mixture adheres to the beating heart in vivo without disrupting its normal rhythm. The electrofunctionalized injectable cardiac stimulator demonstrates a tissue-compatible Young\'s modulus of 21 kPa and a high conductivity of 55 S/cm. The injected electrode facilitates electrocardiogram measurements, regulates heartbeat in vivo, and rectifies arrhythmia. Conductive functionality is maintained for five consecutive days, and no toxicity is observed at the organism, organ, or cellular levels.
摘要：
如果没有干预,心律失常会导致死亡。然而,在运输大量货物的环境中，及时干预可能是具有挑战性的，重型除颤器不切实际，或紧急手术植入心脏刺激设备是不可行的。这里,我们介绍一种可注射的心脏刺激器，装有包含导电聚合物和单体的纳米颗粒溶液的注射器，注射后，在心脏周围形成用于心脏刺激的导电结构。治疗后,电极从体内清除，消除了手术拔除的需要。该混合物在体内粘附于跳动的心脏而不破坏其正常节律。电功能化可注射心脏刺激器显示21kPa的组织相容性杨氏模量和55S/cm的高电导率。注射电极有助于心电图测量，在体内调节心跳，纠正心律不齐。导电功能保持连续五天，在生物体上没有观察到毒性，器官,或细胞水平。
