Abstract：
Diabetic retinopathy (DR) is a microvascular complication of diabetes characterized by neurovascular impairment of the retina. The dysregulation of the mitophagy process occurs before apoptotic cell death and the appearance of vascular damage. In particular, mitochondrial alterations happen during DR development, supporting the hypothesis that mitophagy is negatively correlated to disease progression. This process is mainly regulated by the PTEN-induced putative kinase protein 1 (PINK1)/Parkin pathway whose activation promotes mitophagy. In this review, we will summarize the evidence reported in the literature demonstrating the involvement of the PINK1/Parkin pathway in diabetic retinopathy-induced retinal degeneration.
摘要：
糖尿病视网膜病变（DR）是糖尿病的微血管并发症，其特征是视网膜的神经血管损害。线粒体自噬过程的失调发生在凋亡细胞死亡和血管损伤出现之前。特别是,线粒体改变发生在DR发展过程中，支持线粒体自噬与疾病进展负相关的假设。该过程主要受PTEN诱导的推定激酶蛋白1（PINK1）/Parkin途径调节，其激活促进线粒体自噬。在这次审查中,我们将总结文献中报道的证明PINK1/Parkin通路参与糖尿病性视网膜病变诱导的视网膜变性的证据.
