Abstract：
BACKGROUND: Little is known about the characteristics and occurrence frequencies of rapid eye movements (REMs) during REM sleep in movement disorders.
OBJECTIVE: The aim of this study was to detect and characterize REMs during polysomnographically defined REM sleep as recorded by electro-oculography (EOG) in 12 patients with progressive supranuclear palsy (PSP), 13 patients with Parkinson\'s disease (PD) and 12 healthy controls.
METHODS: Using a modified EOG montage, we developed an algorithm that automatically detects and characterizes REMs during REM sleep based on their presumptive saccadic kinematics.
RESULTS: Compared to PD and healthy controls, REM densities and REM peak velocities were significantly reduced in PSP. These effects were most pronounced in vertical REMs.
CONCLUSIONS: Ocular motor dysfunction, one of the cardinal features of PSP, seems to be equally at play during REM sleep and wakefulness. For future studies, we provide a novel tool for the unbiased analysis of REMs during REM sleep in movement disorders.
OBJECTIVE: The aim of this study was to detect and characterize REMs during polysomnographically defined REM sleep as recorded by electro-oculography (EOG) in 12 patients with progressive supranuclear palsy (PSP), 13 patients with Parkinson\'s disease (PD) and 12 healthy controls.
METHODS: Using a modified EOG montage, we developed an algorithm that automatically detects and characterizes REMs during REM sleep based on their presumptive saccadic kinematics.
RESULTS: Compared to PD and healthy controls, REM densities and REM peak velocities were significantly reduced in PSP. These effects were most pronounced in vertical REMs.
CONCLUSIONS: Ocular motor dysfunction, one of the cardinal features of PSP, seems to be equally at play during REM sleep and wakefulness. For future studies, we provide a novel tool for the unbiased analysis of REMs during REM sleep in movement disorders.
摘要：
背景：关于运动障碍中REM睡眠期间快速眼动（REM）的特征和发生频率知之甚少。
目的：本研究的目的是检测和表征12例进行性核上性麻痹（PSP）患者多导睡眠定义的REM睡眠过程中的REM，13例帕金森病（PD）患者和12例健康对照。
方法：使用修改的EOG蒙太奇，我们开发了一种算法，该算法可以在REM睡眠期间根据其假定的扫视运动学自动检测和表征REM。
结果：与PD和健康对照相比，PSP中的REM密度和REM峰值速度显着降低。这些效应在垂直REM中最为明显。
结论：眼球运动功能障碍，PSP的主要特征之一，在REM睡眠和清醒期间似乎同样发挥作用。对于未来的研究，我们为运动障碍中REM睡眠期间REM的无偏分析提供了一种新的工具。
目的：本研究的目的是检测和表征12例进行性核上性麻痹（PSP）患者多导睡眠定义的REM睡眠过程中的REM，13例帕金森病（PD）患者和12例健康对照。
方法：使用修改的EOG蒙太奇，我们开发了一种算法，该算法可以在REM睡眠期间根据其假定的扫视运动学自动检测和表征REM。
结果：与PD和健康对照相比，PSP中的REM密度和REM峰值速度显着降低。这些效应在垂直REM中最为明显。
结论：眼球运动功能障碍，PSP的主要特征之一，在REM睡眠和清醒期间似乎同样发挥作用。对于未来的研究，我们为运动障碍中REM睡眠期间REM的无偏分析提供了一种新的工具。
