%0 Journal Article
%T Rapid Eye Movements during REM Sleep Differentiate PSP from Parkinson's Disease.
%A Togni C
%A Carpinelli S
%A Valko PO
%A Bockisch C
%A Waldvogel D
%A Werth E
%A Weber KP
%A Valko Y
%J Mov Disord Clin Pract
%V 0
%N 0
%D 2024 Aug 7
%M 39113401
%F 4.514
%R 10.1002/mdc3.14187
%X <B>BACKGROUND: </B>Little is known about the characteristics and occurrence frequencies of rapid eye movements (REMs) during REM sleep in movement disorders.<BR><B>OBJECTIVE: </B>The aim of this study was to detect and characterize REMs during polysomnographically defined REM sleep as recorded by electro-oculography (EOG) in 12 patients with progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD) and 12 healthy controls.<BR><B>METHODS: </B>Using a modified EOG montage, we developed an algorithm that automatically detects and characterizes REMs during REM sleep based on their presumptive saccadic kinematics.<BR><B>RESULTS: </B>Compared to PD and healthy controls, REM densities and REM peak velocities were significantly reduced in PSP. These effects were most pronounced in vertical REMs.<BR><B>CONCLUSIONS: </B>Ocular motor dysfunction, one of the cardinal features of PSP, seems to be equally at play during REM sleep and wakefulness. For future studies, we provide a novel tool for the unbiased analysis of REMs during REM sleep in movement disorders.