{Reference Type}: Journal Article
{Title}: Rapid Eye Movements during REM Sleep Differentiate PSP from Parkinson's Disease.
{Author}: Togni C;Carpinelli S;Valko PO;Bockisch C;Waldvogel D;Werth E;Weber KP;Valko Y;
{Journal}: Mov Disord Clin Pract
{Volume}: 0
{Issue}: 0
{Year}: 2024 Aug 7
{Factor}: 4.514
{DOI}: 10.1002/mdc3.14187
{Abstract}: <B>BACKGROUND: </B>Little is known about the characteristics and occurrence frequencies of rapid eye movements (REMs) during REM sleep in movement disorders.<BR><B>OBJECTIVE: </B>The aim of this study was to detect and characterize REMs during polysomnographically defined REM sleep as recorded by electro-oculography (EOG) in 12 patients with progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD) and 12 healthy controls.<BR><B>METHODS: </B>Using a modified EOG montage, we developed an algorithm that automatically detects and characterizes REMs during REM sleep based on their presumptive saccadic kinematics.<BR><B>RESULTS: </B>Compared to PD and healthy controls, REM densities and REM peak velocities were significantly reduced in PSP. These effects were most pronounced in vertical REMs.<BR><B>CONCLUSIONS: </B>Ocular motor dysfunction, one of the cardinal features of PSP, seems to be equally at play during REM sleep and wakefulness. For future studies, we provide a novel tool for the unbiased analysis of REMs during REM sleep in movement disorders.