Abstract：
BACKGROUND: The mild behavioral impairment checklist (MBI-C) designed to capture neuropsychiatric symptoms in the whole spectrum of elder with or without dementia, have been verified in mild behavioral impairment, mild cognitive impairment and Alzheimer\'s Disease, but never used in the behavioral variant of frontotemporal dementia (bvFTD).
METHODS: Fifty-two patients with bvFTD (mild, n = 30; moderate-severe, n = 22) and 82 community-dwelling elderly individuals (HCs) were enrolled. All subjects were assessed with a full neuropsychological scale including the MBI-C, Neuropsychiatric Inventory Questionnaire (NPI-Q), and Frontal Behavioral Inventory (FBI). Receiver operating characteristic curves were drawn to analyze the sensitivity and specificity of the MBI-C, NPI-Q, and FBI, and cutoff points were determined using the Youden index.
RESULTS: The MBI-C and domain scores in all patients with bvFTD were significantly higher than those in HCs. The most common symptoms of bvFTD were apathy (82.7%) and impulse dyscontrol (80.8%). The MBI-C score was positively correlated with the NPI-Q, FBI, and Activities of Daily Living. For differentiating patients with both bvFTD and mild bvFTD from HCs, the optimal MBI-C cutoff point was 5/6 with a sensitivity of 100% and specificity of 82%, and its sensitivity was higher than that of the NPI-Q and FBI.
CONCLUSIONS: The MBI-C is a sensitive tool for screening behavioral and psychological symptoms in patients with bvFTD, even in the early stages of the disease.
METHODS: Fifty-two patients with bvFTD (mild, n = 30; moderate-severe, n = 22) and 82 community-dwelling elderly individuals (HCs) were enrolled. All subjects were assessed with a full neuropsychological scale including the MBI-C, Neuropsychiatric Inventory Questionnaire (NPI-Q), and Frontal Behavioral Inventory (FBI). Receiver operating characteristic curves were drawn to analyze the sensitivity and specificity of the MBI-C, NPI-Q, and FBI, and cutoff points were determined using the Youden index.
RESULTS: The MBI-C and domain scores in all patients with bvFTD were significantly higher than those in HCs. The most common symptoms of bvFTD were apathy (82.7%) and impulse dyscontrol (80.8%). The MBI-C score was positively correlated with the NPI-Q, FBI, and Activities of Daily Living. For differentiating patients with both bvFTD and mild bvFTD from HCs, the optimal MBI-C cutoff point was 5/6 with a sensitivity of 100% and specificity of 82%, and its sensitivity was higher than that of the NPI-Q and FBI.
CONCLUSIONS: The MBI-C is a sensitive tool for screening behavioral and psychological symptoms in patients with bvFTD, even in the early stages of the disease.
摘要：
背景：轻度行为障碍检查表（MBI-C）旨在捕获所有患有或不患有痴呆症的老年人的神经精神症状，已经在轻度行为障碍中得到证实，轻度认知障碍和阿尔茨海默病，但从未用于额颞叶痴呆（bvFTD）的行为变异。
方法：52例bvFTD患者（轻度，n=30；中度-重度，n=22）和82名社区居住的老年人（HCs）被纳入。所有受试者均采用包括MBI-C在内的完整神经心理学量表进行评估，神经精神调查问卷(NPI-Q)，和正面行为清单（FBI）。绘制受试者工作特征曲线,分析MBI-C,NPI-Q,还有FBI,和截止点是使用Youden指数确定的。
结果：所有bvFTD患者的MBI-C和领域评分均明显高于HC。bvFTD最常见的症状是冷漠(82.7%)和冲动控制障碍(80.8%)。MBI-C评分与NPI-Q呈正相关,联邦调查局,和日常生活活动。为了区分患有bvFTD和轻度bvFTD的患者与HCs，最佳MBI-C截止点为5/6，灵敏度为100%，特异性为82%，其灵敏度高于NPI-Q和FBI。
结论：MBI-C是筛查bvFTD患者行为和心理症状的敏感工具，甚至在疾病的早期阶段。
方法：52例bvFTD患者（轻度，n=30；中度-重度，n=22）和82名社区居住的老年人（HCs）被纳入。所有受试者均采用包括MBI-C在内的完整神经心理学量表进行评估，神经精神调查问卷(NPI-Q)，和正面行为清单（FBI）。绘制受试者工作特征曲线,分析MBI-C,NPI-Q,还有FBI,和截止点是使用Youden指数确定的。
结果：所有bvFTD患者的MBI-C和领域评分均明显高于HC。bvFTD最常见的症状是冷漠(82.7%)和冲动控制障碍(80.8%)。MBI-C评分与NPI-Q呈正相关,联邦调查局,和日常生活活动。为了区分患有bvFTD和轻度bvFTD的患者与HCs，最佳MBI-C截止点为5/6，灵敏度为100%，特异性为82%，其灵敏度高于NPI-Q和FBI。
结论：MBI-C是筛查bvFTD患者行为和心理症状的敏感工具，甚至在疾病的早期阶段。
