METHODS: Fifty-two patients with bvFTD (mild, n = 30; moderate-severe, n = 22) and 82 community-dwelling elderly individuals (HCs) were enrolled. All subjects were assessed with a full neuropsychological scale including the MBI-C, Neuropsychiatric Inventory Questionnaire (NPI-Q), and Frontal Behavioral Inventory (FBI). Receiver operating characteristic curves were drawn to analyze the sensitivity and specificity of the MBI-C, NPI-Q, and FBI, and cutoff points were determined using the Youden index.
RESULTS: The MBI-C and domain scores in all patients with bvFTD were significantly higher than those in HCs. The most common symptoms of bvFTD were apathy (82.7%) and impulse dyscontrol (80.8%). The MBI-C score was positively correlated with the NPI-Q, FBI, and Activities of Daily Living. For differentiating patients with both bvFTD and mild bvFTD from HCs, the optimal MBI-C cutoff point was 5/6 with a sensitivity of 100% and specificity of 82%, and its sensitivity was higher than that of the NPI-Q and FBI.
CONCLUSIONS: The MBI-C is a sensitive tool for screening behavioral and psychological symptoms in patients with bvFTD, even in the early stages of the disease.
方法:52例bvFTD患者(轻度,n=30;中度-重度,n=22)和82名社区居住的老年人(HCs)被纳入。所有受试者均采用包括MBI-C在内的完整神经心理学量表进行评估,神经精神调查问卷(NPI-Q),和正面行为清单(FBI)。绘制受试者工作特征曲线,分析MBI-C,NPI-Q,还有FBI,和截止点是使用Youden指数确定的。
结果:所有bvFTD患者的MBI-C和领域评分均明显高于HC。bvFTD最常见的症状是冷漠(82.7%)和冲动控制障碍(80.8%)。MBI-C评分与NPI-Q呈正相关,联邦调查局,和日常生活活动。为了区分患有bvFTD和轻度bvFTD的患者与HCs,最佳MBI-C截止点为5/6,灵敏度为100%,特异性为82%,其灵敏度高于NPI-Q和FBI。
结论:MBI-C是筛查bvFTD患者行为和心理症状的敏感工具,甚至在疾病的早期阶段。