Abstract：
The objective of the present study was to investigate the frequency of oral leukoplakia and oral erythroplakia among young patients from three Brazilian reference centers in Oral and Maxillofacial Pathology. A retrospective study was carried out from 2011 to 2021 on 861 patients diagnosed with oral leukoplakia and oral erythroplakia. Demographic and clinicopathological data were evaluated. Fisher\'s exact test was used to evaluate the association among sex, age, anatomical location, and histopathological diagnosis. A total of 83 (9.64%) cases involved young patients (aged <40 years). Among these, biopsy records were included in 31 (37.34%) cases, all of which received a clinical diagnosis of oral leukoplakia. Seventeen (54.84%) patients were female, mostly in their fourth decade of life (n = 22/70.97%), and their mean age at diagnosis was 32.61(± 5.21) years. Among informed cases, seven (22.58%) patients were smokers. The lateral border of the tongue (n = 9/29.03%) was the most affected site. In 13 (41.94%) cases, oral leukoplakias showed a homogeneous appearance. The mean size of the lesions was 1.47 cm (0.2-3.0 cm) and the mean time of disease progression was 64.37 (± 65.90) months. The histopathological analysis showed that 11 cases (35.48%) exhibited some degree of epithelial dysplasia. Acanthosis and/or hyperkeratosis were observed in 20 cases (64.52%). No significant associations were observed between sex and anatomical location, age and anatomical location, nor between sex and histological diagnosis (p > 0.05). Oral leukoplakia and oral erythroplakia are uncommon diseases in young patients. In this population, oral leukoplakia shows a slight predilection for women aged between 30 and 39 years.
摘要：
本研究的目的是调查来自三个巴西口腔颌面病理学参考中心的年轻患者中口腔白斑和口腔红斑的频率。从2011年到2021年，对861例诊断为口腔白斑和口腔红斑的患者进行了回顾性研究。评估了人口统计学和临床病理数据。费舍尔的精确检验用于评估性别之间的关联，年龄,解剖位置,和组织病理学诊断。共有83例（9.64％）涉及年轻患者（年龄<40岁）。其中,活检记录包括31例（37.34%），所有这些都接受了口腔白斑的临床诊断。17名(54.84%)患者为女性,大多在他们生命的第四个十年(n=22/70.97%)，他们诊断时的平均年龄为32.61(±5.21)岁。在知情案件中，7例(22.58%)患者为吸烟者。舌侧缘(n=9/29.03%)是受影响最严重的部位。在13例(41.94%)中，口腔白斑表现出均匀的外观。病变的平均大小为1.47cm（0.2-3.0cm），疾病进展的平均时间为64.37（±65.90）个月。组织病理学分析显示11例(35.48%)存在一定程度的上皮异型增生。20例(64.52%)出现棘皮病和/或角化过度。性别和解剖位置之间没有观察到显著的关联，年龄和解剖位置，性别和组织学诊断之间也没有（p>0.05）。口腔白斑和口腔红斑是年轻患者的罕见疾病。在这个人群中,口腔白斑对30至39岁的女性有轻微的好感。
