Abstract：
UNASSIGNED: Little is known about the relationship between neighborhood disadvantage and neuromyelitis optica spectrum disorder (NMOSD) outcomes.
UNASSIGNED: The objective is to determine the impact of neighborhood disadvantage on time from symptom onset to diagnosis and annualized relapse rate (ARR).
UNASSIGNED: Neighborhood disadvantage were captured with the Area Deprivation Index (ADI), a validated measure of neighborhood-level disadvantage. Negative binomial regression models assessed the impact of ADI on diagnostic delay (⩾3 months between symptom onset and diagnosis) and ARR.
UNASSIGNED: A total of 158 NMOSD patients were identified, a majority of whom were White (56.3%) and female (89.9%) with a mean age of 46 years at diagnosis. The ADI did not significantly affect odds of diagnostic delay (odds ratio (OR) = 0.99, p = 0.26). In univariable models, the ADI was not significantly associated with ARR (OR = 1.004, p = 0.29), but non-White race (OR = 1.541, p = 0.02) and time on immunosuppressive therapies (ISTs; OR = 0.994, p = 0.03) were. White patients used IST for an average of 81% of the follow-up period, compared to an average of 65% for non-White patients (p < 0.01).
UNASSIGNED: No significant relationship between neighborhood-level disadvantage and diagnostic delay or ARR in NMOSD patients was observed. Non-White patients had a higher ARR, which may be related to less IST use.
UNASSIGNED: The objective is to determine the impact of neighborhood disadvantage on time from symptom onset to diagnosis and annualized relapse rate (ARR).
UNASSIGNED: Neighborhood disadvantage were captured with the Area Deprivation Index (ADI), a validated measure of neighborhood-level disadvantage. Negative binomial regression models assessed the impact of ADI on diagnostic delay (⩾3 months between symptom onset and diagnosis) and ARR.
UNASSIGNED: A total of 158 NMOSD patients were identified, a majority of whom were White (56.3%) and female (89.9%) with a mean age of 46 years at diagnosis. The ADI did not significantly affect odds of diagnostic delay (odds ratio (OR) = 0.99, p = 0.26). In univariable models, the ADI was not significantly associated with ARR (OR = 1.004, p = 0.29), but non-White race (OR = 1.541, p = 0.02) and time on immunosuppressive therapies (ISTs; OR = 0.994, p = 0.03) were. White patients used IST for an average of 81% of the follow-up period, compared to an average of 65% for non-White patients (p < 0.01).
UNASSIGNED: No significant relationship between neighborhood-level disadvantage and diagnostic delay or ARR in NMOSD patients was observed. Non-White patients had a higher ARR, which may be related to less IST use.
摘要：
■关于邻域劣势与视神经脊髓炎谱系障碍（NMOSD）结果之间的关系知之甚少。
■目的是确定邻里劣势对从症状发作到诊断和年度复发率（ARR）的时间的影响。
■通过区域剥夺指数（ADI）捕获了邻里劣势，一种经过验证的邻域水平劣势度量。负二项回归模型评估了ADI对诊断延迟（症状发作和诊断之间的3个月）和ARR的影响。
■共确定了158名NMOSD患者，其中大多数为白人(56.3%)和女性(89.9%),诊断时平均年龄为46岁.ADI没有显著影响诊断延迟的几率(比值比(OR)=0.99,p=0.26)。在单变量模型中，ADI与ARR无显著相关性(OR=1.004,p=0.29),但非白种人（OR=1.541，p=0.02）和免疫抑制治疗时间（ISTS；OR=0.994，p=0.03）。白人患者使用IST平均81%的随访期，与非白人患者的平均65%相比(p<0.01)。
■在NMOSD患者中，未观察到邻域水平劣势与诊断延迟或ARR之间的显着关系。非白人患者的ARR较高，这可能与较少的IST使用有关。
■目的是确定邻里劣势对从症状发作到诊断和年度复发率（ARR）的时间的影响。
■通过区域剥夺指数（ADI）捕获了邻里劣势，一种经过验证的邻域水平劣势度量。负二项回归模型评估了ADI对诊断延迟（症状发作和诊断之间的3个月）和ARR的影响。
■共确定了158名NMOSD患者，其中大多数为白人(56.3%)和女性(89.9%),诊断时平均年龄为46岁.ADI没有显著影响诊断延迟的几率(比值比(OR)=0.99,p=0.26)。在单变量模型中，ADI与ARR无显著相关性(OR=1.004,p=0.29),但非白种人（OR=1.541，p=0.02）和免疫抑制治疗时间（ISTS；OR=0.994，p=0.03）。白人患者使用IST平均81%的随访期，与非白人患者的平均65%相比(p<0.01)。
■在NMOSD患者中，未观察到邻域水平劣势与诊断延迟或ARR之间的显着关系。非白人患者的ARR较高，这可能与较少的IST使用有关。
