{Reference Type}: Journal Article
{Title}: Neighborhood disadvantage, race, and clinical outcomes in neuromyelitis optica spectrum disorder.
{Author}: Abbatemarco JR;Aboseif A;Swetlik C;Widmar J;Harvey T;Kunchok A;O'Mahony J;Miller DM;Conway DS;
{Journal}: Mult Scler
{Volume}: 0
{Issue}: 0
{Year}: 2024 Aug 6
{Factor}: 5.855
{DOI}: 10.1177/13524585241267231
{Abstract}: <B>UNASSIGNED: </B>Little is known about the relationship between neighborhood disadvantage and neuromyelitis optica spectrum disorder (NMOSD) outcomes.<BR><B>UNASSIGNED: </B>The objective is to determine the impact of neighborhood disadvantage on time from symptom onset to diagnosis and annualized relapse rate (ARR).<BR><B>UNASSIGNED: </B>Neighborhood disadvantage were captured with the Area Deprivation Index (ADI), a validated measure of neighborhood-level disadvantage. Negative binomial regression models assessed the impact of ADI on diagnostic delay (⩾3 months between symptom onset and diagnosis) and ARR.<BR><B>UNASSIGNED: </B>A total of 158 NMOSD patients were identified, a majority of whom were White (56.3%) and female (89.9%) with a mean age of 46 years at diagnosis. The ADI did not significantly affect odds of diagnostic delay (odds ratio (OR) = 0.99, p = 0.26). In univariable models, the ADI was not significantly associated with ARR (OR = 1.004, p = 0.29), but non-White race (OR = 1.541, p = 0.02) and time on immunosuppressive therapies (ISTs; OR = 0.994, p = 0.03) were. White patients used IST for an average of 81% of the follow-up period, compared to an average of 65% for non-White patients (p < 0.01).<BR><B>UNASSIGNED: </B>No significant relationship between neighborhood-level disadvantage and diagnostic delay or ARR in NMOSD patients was observed. Non-White patients had a higher ARR, which may be related to less IST use.