PDF(Pubmed)
Abstract：
The analysis of cardiac wall mechanics is of importance for understanding coronary heart diseases (CHD). The inhalation of ultrafine particles could deteriorate CHD. The aim of the study is to investigate the effects of cardiac wall mechanics on rats of myocardial infarction (MI) after long-term inhalation of ultrafine Zn particles. Cardiac wall stresses and strains were computed, based on echocardiographic and hemodynamic measurements. It was found that MI resulted in the significantly elevated stresses and the reduced strains. The short-term inhalation of ultrafine Zn particles decreased stresses and increased strains in MI rats, but the long-term inhalation had the opposite effects. Hence, the short-term inhalation of ultrafine Zn particles could alleviate the MI-induced LV dysfunction while the long-term inhalation impaired it.
摘要：
心脏壁力学分析对于了解冠心病（CHD）很重要。吸入超细颗粒可使CHD恶化。该研究的目的是研究长期吸入超细锌颗粒后，心脏壁力学对心肌梗死（MI）大鼠的影响。计算心壁应力和应变，基于超声心动图和血流动力学测量。发现MI导致显著升高的应力和降低的应变。短期吸入超细锌颗粒降低了MI大鼠的应激和增加的应变，但是长期吸入会产生相反的效果。因此，短期吸入超细锌颗粒可减轻MI引起的LV功能障碍，而长期吸入可减轻其损害。
