PDF(Pubmed)
Abstract：
OBJECTIVE: Changes in treatment approaches, characterised by the shift from laryngectomy to a focus on organ-preserving methods may have potentially resulted in lower survival. We aim to identify differences in survival trends for laryngeal cancer (LC) in the Nordic countries over a period of 50 years, and discuss the potential impact of factors such as changes in treatment protocols.
METHODS: Five-year relative survival (RS) data from 1972 to 2021 were obtained from the NORDCAN database 2.0 which included 33,692 LC cases, of which 85% were diagnosed among men. In the NORDCAN database, the age-standardised RS is calculated using the Pohar Perme estimator with individual International Cancer Survival Standards weights. Joinpoint regression models were used to assess potential shifts in trend over the years in RS.
RESULTS: While Denmark and Norway demonstrated an increasing trend in 5-year RS from 1972 to 2021, in Finland and Sweden, the 5-year RS among men remained static, without any discernible significant trend. Over the 30-year period from 1992-1996 to 2017-2021, RS improved by 9, 4, 13, and 2 percentage points in Denmark, Finland, Norway, and Sweden, respectively. Among women in Sweden, a linear negative trend was observed, noticeable as a 16 percentage-point decline in 5-year RS from the earliest to the latest period.
CONCLUSIONS: The underlying causes for the differences in survival trends remain unclear. Besides differences in treatment protocols, several other factors can affect RS making the interpretation of RS trends challenging.
METHODS: Five-year relative survival (RS) data from 1972 to 2021 were obtained from the NORDCAN database 2.0 which included 33,692 LC cases, of which 85% were diagnosed among men. In the NORDCAN database, the age-standardised RS is calculated using the Pohar Perme estimator with individual International Cancer Survival Standards weights. Joinpoint regression models were used to assess potential shifts in trend over the years in RS.
RESULTS: While Denmark and Norway demonstrated an increasing trend in 5-year RS from 1972 to 2021, in Finland and Sweden, the 5-year RS among men remained static, without any discernible significant trend. Over the 30-year period from 1992-1996 to 2017-2021, RS improved by 9, 4, 13, and 2 percentage points in Denmark, Finland, Norway, and Sweden, respectively. Among women in Sweden, a linear negative trend was observed, noticeable as a 16 percentage-point decline in 5-year RS from the earliest to the latest period.
CONCLUSIONS: The underlying causes for the differences in survival trends remain unclear. Besides differences in treatment protocols, several other factors can affect RS making the interpretation of RS trends challenging.
摘要：
目的：治疗方法的变化，特征是从喉切除术转向关注器官保存方法可能导致生存率降低。我们的目标是确定北欧国家50年期间喉癌（LC）生存趋势的差异，并讨论治疗方案变化等因素的潜在影响。
方法：1972年至2021年的五年相对生存（RS）数据来自NORDCAN数据库2.0，其中包括33,692例LC病例，其中85%被诊断为男性。在NORDCAN数据库中，年龄标准化RS是使用PoharPerme估计器和单个国际癌症生存标准权重计算的。Joinpoint回归模型用于评估RS多年来趋势的潜在变化。
结果：尽管丹麦和挪威在1972年至2021年的5年RS中表现出增长趋势，但在芬兰和瑞典，男性的5年RS保持不变，没有任何明显的趋势。在1992-1996年至2017-2021年的30年间，丹麦的RS分别提高了9、4、13和2个百分点。芬兰,挪威,瑞典,分别。在瑞典的女性中，观察到线性负趋势，值得注意的是，从最早到最近一段时间，5年期RS下降了16个百分点。
结论：生存趋势差异的根本原因尚不清楚。除了治疗方案的差异，其他几个因素也会影响RS，这使得RS趋势的解释具有挑战性。
方法：1972年至2021年的五年相对生存（RS）数据来自NORDCAN数据库2.0，其中包括33,692例LC病例，其中85%被诊断为男性。在NORDCAN数据库中，年龄标准化RS是使用PoharPerme估计器和单个国际癌症生存标准权重计算的。Joinpoint回归模型用于评估RS多年来趋势的潜在变化。
结果：尽管丹麦和挪威在1972年至2021年的5年RS中表现出增长趋势，但在芬兰和瑞典，男性的5年RS保持不变，没有任何明显的趋势。在1992-1996年至2017-2021年的30年间，丹麦的RS分别提高了9、4、13和2个百分点。芬兰,挪威,瑞典,分别。在瑞典的女性中，观察到线性负趋势，值得注意的是，从最早到最近一段时间，5年期RS下降了16个百分点。
结论：生存趋势差异的根本原因尚不清楚。除了治疗方案的差异，其他几个因素也会影响RS，这使得RS趋势的解释具有挑战性。
