Abstract：
Herein we report a wearable sweat sensor of a Janus fabric based on surface enhanced Raman scattering (SERS) technology, mainly detecting the two important metabolites glucose and lactate. Janus fabric is composed of electrospinning PU on a piece of medical gauze (cotton), working as the unidirectional moisture transport component (R = 1305%) to collect and transfer sweat efficiently. SERS tags with different structures act as the probe to recognize and detect the glucose and lactate in high sensitivity. Core-shell structured gold nanorods with DTNB inside (AuNRs@DTNB@Au) are used to detect lactate, while gold nanorods with MPBA (AuNRs@MPBA) are used to detect glucose. Through the characteristic SERS information, two calibration functions were established for the concentration determination of glucose and lactate. The concentrations of glucose and lactate in sweat of a 23 years volunteer during three-stage interval running are tested to be 95.5, 53.2, 30.5 μM and 4.9, 13.9, 10.8 mM, indicating the glucose (energy) consumption during exercise and the rapid accumulation of lactate at the early stage accompanied by the subsequent relief. As expected, this sensing system is able to provide a novel strategy for effective acquisition and rapid detection of essential biomarkers in sweat.
摘要：
在这里，我们报告了一种基于表面增强拉曼散射（SERS）技术的Janus织物的可穿戴汗液传感器，主要检测两种重要的代谢产物葡萄糖和乳酸。Janus织物由在一块医用纱布（棉）上静电纺丝PU组成，作为单向水分输送组件（R=1305%）有效地收集和转移汗水。具有不同结构的SERS标签作为探针以高灵敏度识别和检测葡萄糖和乳酸。内部带有DTNB的核壳结构金纳米棒（AuNRs@DTNB@Au）用于检测乳酸，而金纳米棒与MPBA(AuNRs@MPBA)用于检测葡萄糖。通过特征SERS信息，建立了葡萄糖和乳酸浓度测定的两个校准函数。在三个阶段的间歇跑步过程中，23岁志愿者的汗液中葡萄糖和乳酸的浓度被测试为95.5、53.2、30.5μM和4.9、13.9、10.8mM，表明运动过程中的葡萄糖（能量）消耗以及早期乳酸的快速积累，并伴随着随后的缓解。不出所料,该传感系统能够为有效获取和快速检测汗液中的必需生物标志物提供新的策略。
