Abstract：
BACKGROUND: This study aimed to explore the risk factors for chronic cough in children and provide a reference for prevention and healthcare measures.
METHODS: PubMed, Web of Science, Cochrane, and EMBASE were searched for observational studies published up to April 2024. Outcome included risk factors associated with chronic cough in children. Two investigators independently searched and screened the literature, evaluated the qualities and extracted baseline datas. Results were analyzed using random-effects models with odds ratios and their 95 % confidence intervals to address heterogeneity. Subgroup analyses, sensitivity analyses and assessment of publication bias were performed. Stata17 and GRADEwas used for the meta-analysis.
RESULTS: 18 studies including 97,462 children were reviewed. Asthma(OR = 4.06, 95%CI: 2.37-6.96, P＜0.01), NO2(OR = 1.19, 95%CI: 1.01-1.39, P = 0.031), Home remodeling history (OR = 1.82,95 % CI: 1.61-2.05, P＜0.01), Environment Tobacco Smoke(OR = 1.41, 95 % CI: 1.15-1.73, P = 0.001), Pet exposure (OR = 1.56, 95%CI: 1.25-1.95, P＜0.01), Mould (OR = 1.64,95%CI: 1.45-1.85, P＜0.01), Age＜1 year(OR = 3.19, 95 % CI: 1.8-5.63, P＜0.01) were reported as risk factors for chronic cough in children, these results were discussed qualitatively in the study.
CONCLUSIONS: Asthma, NO2, Home remodeling history, Environment Tobacco Smoke(ETS), Pet exposure, Mould, and Age＜1 year are risk factors for chronic coughing in children. Due to the few studies and insufficient evidence, other potential risk factors need to be robustly confirmed by subsequent large-sample and multicenter trials.
METHODS: PubMed, Web of Science, Cochrane, and EMBASE were searched for observational studies published up to April 2024. Outcome included risk factors associated with chronic cough in children. Two investigators independently searched and screened the literature, evaluated the qualities and extracted baseline datas. Results were analyzed using random-effects models with odds ratios and their 95 % confidence intervals to address heterogeneity. Subgroup analyses, sensitivity analyses and assessment of publication bias were performed. Stata17 and GRADEwas used for the meta-analysis.
RESULTS: 18 studies including 97,462 children were reviewed. Asthma(OR = 4.06, 95%CI: 2.37-6.96, P＜0.01), NO2(OR = 1.19, 95%CI: 1.01-1.39, P = 0.031), Home remodeling history (OR = 1.82,95 % CI: 1.61-2.05, P＜0.01), Environment Tobacco Smoke(OR = 1.41, 95 % CI: 1.15-1.73, P = 0.001), Pet exposure (OR = 1.56, 95%CI: 1.25-1.95, P＜0.01), Mould (OR = 1.64,95%CI: 1.45-1.85, P＜0.01), Age＜1 year(OR = 3.19, 95 % CI: 1.8-5.63, P＜0.01) were reported as risk factors for chronic cough in children, these results were discussed qualitatively in the study.
CONCLUSIONS: Asthma, NO2, Home remodeling history, Environment Tobacco Smoke(ETS), Pet exposure, Mould, and Age＜1 year are risk factors for chronic coughing in children. Due to the few studies and insufficient evidence, other potential risk factors need to be robustly confirmed by subsequent large-sample and multicenter trials.
摘要：
背景：本研究旨在探讨儿童慢性咳嗽的危险因素，为预防和保健措施提供参考。
方法：PubMed，WebofScience,科克伦,和EMBASE搜索了截至2024年4月发表的观察性研究。结果包括与儿童慢性咳嗽相关的危险因素。两名研究者独立搜索和筛选文献，评估质量并提取基线数据。使用具有优势比及其95％置信区间的随机效应模型对结果进行分析，以解决异质性。亚组分析，我们进行了敏感性分析和发表偏倚评估.使用Stata17和GRADE进行荟萃分析。
结果：回顾了18项研究，包括97,462名儿童。哮喘(OR=4.06,95CI:2.37～6.96,P＜0.01),NO2(OR=1.19,95CI:1.01-1.39,P=0.031),家庭重塑史(OR=1.82,95%CI:1.61～2.05,P＜0.01),环境烟草烟雾(OR=1.41,95%CI:1.15-1.73,P=0.001),宠物暴露(OR=1.56,95CI:1.25～1.95,P＜0.01),模具(OR=1.64,95CI:1.45-1.85,P＜0.01),年龄＜1岁（OR=3.19，95%CI：1.8～5.63，P＜0.01）是儿童慢性咳嗽的危险因素。本研究对这些结果进行了定性讨论.
结论：哮喘，NO2,家庭改造史,环境烟草烟雾（ETS），宠物暴露,模具,年龄＜1岁是儿童慢性咳嗽的危险因素。由于研究较少，证据不足，其他潜在的危险因素需要通过后续的大样本和多中心试验得到有力证实.
方法：PubMed，WebofScience,科克伦,和EMBASE搜索了截至2024年4月发表的观察性研究。结果包括与儿童慢性咳嗽相关的危险因素。两名研究者独立搜索和筛选文献，评估质量并提取基线数据。使用具有优势比及其95％置信区间的随机效应模型对结果进行分析，以解决异质性。亚组分析，我们进行了敏感性分析和发表偏倚评估.使用Stata17和GRADE进行荟萃分析。
结果：回顾了18项研究，包括97,462名儿童。哮喘(OR=4.06,95CI:2.37～6.96,P＜0.01),NO2(OR=1.19,95CI:1.01-1.39,P=0.031),家庭重塑史(OR=1.82,95%CI:1.61～2.05,P＜0.01),环境烟草烟雾(OR=1.41,95%CI:1.15-1.73,P=0.001),宠物暴露(OR=1.56,95CI:1.25～1.95,P＜0.01),模具(OR=1.64,95CI:1.45-1.85,P＜0.01),年龄＜1岁（OR=3.19，95%CI：1.8～5.63，P＜0.01）是儿童慢性咳嗽的危险因素。本研究对这些结果进行了定性讨论.
结论：哮喘，NO2,家庭改造史,环境烟草烟雾（ETS），宠物暴露,模具,年龄＜1岁是儿童慢性咳嗽的危险因素。由于研究较少，证据不足，其他潜在的危险因素需要通过后续的大样本和多中心试验得到有力证实.
