PDF(Pubmed)
Abstract：
As humans age, some experience cognitive impairment while others do not. When impairment does occur, it is not expressed uniformly across cognitive domains and varies in severity across individuals. Translationally relevant model systems are critical for understanding the neurobiological drivers of this variability, which is essential to uncovering the mechanisms underlying the brain\'s susceptibility to the effects of aging. As such, non-human primates are particularly important due to shared behavioral, neuroanatomical, and age-related neuropathological features with humans. For many decades, macaque monkeys have served as the primary non-human primate model for studying the neurobiology of cognitive aging. More recently, the common marmoset has emerged as an advantageous model for this work due to its short lifespan that facilitates longitudinal studies. Despite their growing popularity as a model, whether marmosets exhibit patterns of age-related cognitive impairment comparable to those observed in macaques and humans remains unexplored. To address this major limitation for the development and evaluation of the marmoset as a model of cognitive aging, we directly compared working memory ability as a function of age in macaques and marmosets on the identical working memory task. Our results demonstrate that marmosets and macaques exhibit remarkably similar age-related working memory deficits, highlighting the value of the marmoset as a model for cognitive aging research within the neuroscience community.
摘要：
随着人类年龄的增长,一些经历认知障碍，而其他人没有。当确实发生损害时，它在认知领域的表达并不统一，并且在个体之间的严重程度也不同。翻译相关的模型系统对于理解这种变异性的神经生物学驱动因素至关重要，这对于揭示大脑对衰老影响的易感性的潜在机制至关重要。因此，由于共同的行为，非人灵长类动物尤为重要，神经解剖学,与人类年龄相关的神经病理学特征。几十年来,猕猴已成为研究认知衰老神经生物学的主要非人灵长类动物模型。最近,常见的marmoset已成为这项工作的一个有利的模型，由于它的短寿命，有利于纵向研究。尽管他们作为模特越来越受欢迎，在猕猴和人类中观察到的与年龄相关的认知障碍模式是否具有可比性仍有待研究.为了解决作为认知衰老模型的mar猴的发展和评估的主要局限性，在相同的工作记忆任务中，我们直接比较了猕猴和猕猴的工作记忆能力随年龄的变化。我们的结果表明，猕猴和猕猴表现出与年龄相关的工作记忆缺陷非常相似，突出的价值，作为一个模型，在神经科学界认知衰老研究。
