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Abstract：
BACKGROUND: We investigated the feasibility of the tertiary lymphoid structure (TLS) as a prognostic marker for penile squamous cell carcinoma(SCC).
METHODS: We retrospectively collected data from 83 patients with penile squamous cell carcinoma. H&E-stained slides were reviewed for TLS density. In addition, clinical parameters were analyzed, the prognostic value of these parameters on overall survival (OS) was evaluated using ‒ Kaplan-Meier survival curves, and the prognostic value of influencing factors was evaluated using Cox multifactor design nomogram analysis.
RESULTS: BMI, T, N, and M are significant in the survival curve with or without tertiary lymphoid structure. BMI, T, N, M and TLS were used to construct a prognostic model for penile squamous cell carcinoma, and the prediction accuracy reached a consensus of 0.884(0.835-0.932), and the decision consensus reached 0.581(0.508-0.655).
CONCLUSIONS: TLS may be a positive prognostic factor for penile squamous cell carcinoma, and the combination of BMI, T, N and M can better evaluate the prognosis of patients.
METHODS: We retrospectively collected data from 83 patients with penile squamous cell carcinoma. H&E-stained slides were reviewed for TLS density. In addition, clinical parameters were analyzed, the prognostic value of these parameters on overall survival (OS) was evaluated using ‒ Kaplan-Meier survival curves, and the prognostic value of influencing factors was evaluated using Cox multifactor design nomogram analysis.
RESULTS: BMI, T, N, and M are significant in the survival curve with or without tertiary lymphoid structure. BMI, T, N, M and TLS were used to construct a prognostic model for penile squamous cell carcinoma, and the prediction accuracy reached a consensus of 0.884(0.835-0.932), and the decision consensus reached 0.581(0.508-0.655).
CONCLUSIONS: TLS may be a positive prognostic factor for penile squamous cell carcinoma, and the combination of BMI, T, N and M can better evaluate the prognosis of patients.
摘要：
背景：我们研究了三级淋巴结构（TLS）作为阴茎鳞状细胞癌（SCC）预后标志物的可行性。
方法：我们回顾性收集了83例阴茎鳞状细胞癌患者的资料。审查H&E染色的载玻片的TLS密度。此外,分析临床参数，使用Kaplan-Meier生存曲线评估这些参数对总生存期（OS）的预后价值，采用Cox多因素设计列线图分析评价影响因素的预后价值。
结果：BMI，T,N,和M在有或没有三级淋巴样结构的存活曲线中都很重要。BMI,T,N,M和TLS用于构建阴茎鳞状细胞癌的预后模型，预测精度达到0.884(0.835-0.932)的一致性，决策共识达到0.581(0.508-0.655)。
结论：TLS可能是阴茎鳞状细胞癌的积极预后因素，以及BMI的组合，T,N和M能更好地评价患者的预后。
方法：我们回顾性收集了83例阴茎鳞状细胞癌患者的资料。审查H&E染色的载玻片的TLS密度。此外,分析临床参数，使用Kaplan-Meier生存曲线评估这些参数对总生存期（OS）的预后价值，采用Cox多因素设计列线图分析评价影响因素的预后价值。
结果：BMI，T,N,和M在有或没有三级淋巴样结构的存活曲线中都很重要。BMI,T,N,M和TLS用于构建阴茎鳞状细胞癌的预后模型，预测精度达到0.884(0.835-0.932)的一致性，决策共识达到0.581(0.508-0.655)。
结论：TLS可能是阴茎鳞状细胞癌的积极预后因素，以及BMI的组合，T,N和M能更好地评价患者的预后。
