%0 Journal Article
%T A model of tertiary lymphatic structure-related prognosis for penile squamous cell carcinoma.
%A Tang H
%A Su Z
%A Huang Q
%A Li Y
%A Chen R
%A Ban C
%A Liu C
%A Lu H
%A Yi XL
%A Tang Y
%J BMC Urol
%V 24
%N 1
%D 2024 Aug 2
%M 39090582
%F 2.09
%R 10.1186/s12894-024-01532-6
%X <B>BACKGROUND: </B>We investigated the feasibility of the tertiary lymphoid structure (TLS) as a prognostic marker for penile squamous cell carcinoma(SCC).<BR><B>METHODS: </B>We retrospectively collected data from 83 patients with penile squamous cell carcinoma. H&E-stained slides were reviewed for TLS density. In addition, clinical parameters were analyzed, the prognostic value of these parameters on overall survival (OS) was evaluated using ‒ Kaplan-Meier survival curves, and the prognostic value of influencing factors was evaluated using Cox multifactor design nomogram analysis.<BR><B>RESULTS: </B>BMI, T, N, and M are significant in the survival curve with or without tertiary lymphoid structure. BMI, T, N, M and TLS were used to construct a prognostic model for penile squamous cell carcinoma, and the prediction accuracy reached a consensus of 0.884(0.835-0.932), and the decision consensus reached 0.581(0.508-0.655).<BR><B>CONCLUSIONS: </B>TLS may be a positive prognostic factor for penile squamous cell carcinoma, and the combination of BMI, T, N and M can better evaluate the prognosis of patients.