METHODS: Annual data on incident cases, mortality, and disability-adjusted life years (DALYs) for NTDs were procured from the Global Burden of Disease Study 2019 (GBD 2019). These data were stratified by global and regional distribution, country, social development index (SDI), age, and sex. We computed age-standardized rates (ASRs) and the numbers of incident cases, mortalities, and DALYs from 1990 to 2019. The estimated annual percentage change (EAPC) in the ASRs was calculated to evaluate evolving trends.
RESULTS: In 2019, it was estimated that there were approximately 552 million NTD cases globally (95% Uncertainty Interval [UI]: 519.9 million to 586.3 million), a 29% decrease since 1990. South Asia reported the highest NTD prevalence, with an estimated 171.7 million cases (95% UI: 150.4 million to 198.6 million). Among the five SDI categories, the prevalence of NTDs was highest in the moderate and low SDI regions in 1990 (approximately 270.5 million cases) and 2019 (approximately 176.5 million cases). Sub-Saharan Africa recorded the most significant decline in NTD cases over the past three decades. Overall, there was a significant inverse correlation between the disease burden of NTDs and SDI.
CONCLUSIONS: NTDs imposed over half a billion incident cases and 10.8 million DALYs lost globally in 2019-exerting an immense toll rivaling major infectious and non-communicable diseases. Encouraging declines in prevalence and disability burdens over the past three decades spotlight the potential to accelerate progress through evidence-based allocation of resources. Such strategic integration could substantially enhance public awareness about risk factors and available treatment options.
方法:事故病例的年度数据,死亡率,NTDs的残疾调整寿命年(DALYs)来自2019年全球疾病负担研究(GBD2019)。这些数据按全球和地区分布分层,国家,社会发展指数(SDI)年龄,和性爱。我们计算了年龄标准化率(ASR)和事件病例数,死亡率,和DALY从1990年到2019年。计算ASR中估计的年度百分比变化(EAPC)以评估不断变化的趋势。
结果:在2019年,估计全球约有5.52亿NTD病例(95%不确定性区间[UI]:5.199亿-5.863亿),自1990年以来下降了29%。南亚报告NTD患病率最高,估计有1.717亿例(95%UI:1.504亿至1.986亿例)。在五个SDI类别中,1990年和2019年,中、低SDI地区的NTDs患病率最高(约2.705亿例).在过去三十年中,撒哈拉以南非洲的NTD病例下降幅度最大。总的来说,NTDs的疾病负担与SDI呈显著负相关。
结论:2019年,NTDs在全球造成了超过5亿例事故病例和1,080万DALYs损失,这与主要传染病和非传染性疾病形成了巨大的差距。在过去的三十年中,患病率和残疾负担令人鼓舞地下降,这凸显了通过基于证据的资源分配来加快进展的潜力。这种战略整合可以大大提高公众对风险因素和可用治疗方案的认识。