Abstract：
In female Wistar rats with breast cancer, quantitative changes of pro-oncogenic miRNAs (miR-21, -27a, and -221) and tumor-suppressive miR-429 in the mesenteric lymph node were assessed after photodynamic therapy for breast cancer and after photodynamic therapy followed surgical treatment. The level of pro-oncogenic miR-221 in the mesenteric lymph node decreased, and the level of pro-oncogenic miR-21 increased after photodynamic therapy for breast cancer followed by surgical treatment in comparison with the corresponding parameters after photodynamic therapy alone. The content of tumor-suppressive miR-429 remained reduced, as in the group of animals receiving photodynamic therapy alone.
摘要：
在患有乳腺癌的雌性Wistar大鼠中，原癌miRNA的定量变化(miR-21，-27a，和-221）和肠系膜淋巴结中的肿瘤抑制性miR-429在乳腺癌的光动力治疗后以及在手术治疗后的光动力治疗后进行评估。肠系膜淋巴结中原癌基因miR-221的水平降低，与单纯光动力治疗后的相应参数相比，乳腺癌光动力治疗后的原癌miR-21水平增加。肿瘤抑制性miR-429的含量仍然降低，与仅接受光动力疗法的动物组一样。
