{Reference Type}: Journal Article
{Title}: Influence of Photodynamic Therapy with Subsequent Surgical Treatment of Experimental Breast Cancer on Quantitative Changes in miRNAs in a Mesenteric Lymph Node.
{Author}: Kabakov AV;Kazakov OV;Poveshchenko AF;Cherkas VN;Kononchuk VV;
{Journal}: Bull Exp Biol Med
{Volume}: 177
{Issue}: 2
{Year}: 2024 Jun 1
{Factor}: 0.737
{DOI}: 10.1007/s10517-024-06171-3
{Abstract}: In female Wistar rats with breast cancer, quantitative changes of pro-oncogenic miRNAs (miR-21, -27a, and -221) and tumor-suppressive miR-429 in the mesenteric lymph node were assessed after photodynamic therapy for breast cancer and after photodynamic therapy followed surgical treatment. The level of pro-oncogenic miR-221 in the mesenteric lymph node decreased, and the level of pro-oncogenic miR-21 increased after photodynamic therapy for breast cancer followed by surgical treatment in comparison with the corresponding parameters after photodynamic therapy alone. The content of tumor-suppressive miR-429 remained reduced, as in the group of animals receiving photodynamic therapy alone.