PDF(Pubmed)
Abstract：
UNASSIGNED: Deep angiomyxoma (DAM) is a slow-growing benign tumor with high risk of local recurrence after surgical resection. Although DAM in a lower extremity is extremely rare, clinicians must be aware of its possible occurrence. Suspicion can be made based on clinical examination and radiological imaging but final diagnosis is confirmed on histopathological examination and immunohistochemistry. We intend to present an extremely rare case of DAM in the knee, managed successfully with marginal excision.
UNASSIGNED: A 4-year-old male child presented with the complains of a painless, progressively increasing, soft, non-tender, and fluctuant swelling in his right knee. The plain radiograph showed a non-calcified soft-tissue swelling and MRI revealed a multi-loculated cystic lesion with multiple septations. A pre-operative diagnosis of a benign cystic lesion was made. It was managed by marginal excision of the tumor and a histological diagnosis of DAM was made. IHC staining showed positivity for SMA, CD34 and vimentin were focally positive, while desmin and calponin were negative. At 12 months of follow-up, the patient had a normal painless gait and full knee ROM, without any local recurrence.
UNASSIGNED: DAM is a rare tumor which is often misdiagnosed. In this report, we present a rare case of benign cystic lesion which turned out to be DAM on HPE of resected specimen. Marginal excision of this lesion revealed good outcomes with no recurrence until 12 months of final follow-up. With this, we conclude that surgical excision should be the gold standard in cases of DAM.
UNASSIGNED: A 4-year-old male child presented with the complains of a painless, progressively increasing, soft, non-tender, and fluctuant swelling in his right knee. The plain radiograph showed a non-calcified soft-tissue swelling and MRI revealed a multi-loculated cystic lesion with multiple septations. A pre-operative diagnosis of a benign cystic lesion was made. It was managed by marginal excision of the tumor and a histological diagnosis of DAM was made. IHC staining showed positivity for SMA, CD34 and vimentin were focally positive, while desmin and calponin were negative. At 12 months of follow-up, the patient had a normal painless gait and full knee ROM, without any local recurrence.
UNASSIGNED: DAM is a rare tumor which is often misdiagnosed. In this report, we present a rare case of benign cystic lesion which turned out to be DAM on HPE of resected specimen. Marginal excision of this lesion revealed good outcomes with no recurrence until 12 months of final follow-up. With this, we conclude that surgical excision should be the gold standard in cases of DAM.
摘要：
■深部血管粘液瘤（DAM）是一种生长缓慢的良性肿瘤，手术切除后局部复发的风险很高。虽然下肢的DAM极为罕见,临床医生必须意识到它的可能发生。可以根据临床检查和放射影像学进行怀疑，但最终诊断在组织病理学检查和免疫组织化学上得到证实。我们打算介绍一个极其罕见的膝盖DAM病例，边缘切除成功管理。
■一个4岁的男孩被无痛的抱怨，逐步增加,软,非招标，右膝肿胀波动.X线平片显示无钙化的软组织肿胀，MRI显示多部位囊性病变伴多发隔膜。术前诊断为良性囊性病变。通过边缘切除肿瘤进行管理，并进行了DAM的组织学诊断。免疫组化染色显示SMA阳性,CD34和波形蛋白呈局灶性阳性，而desmin和calponin呈阴性。在12个月的随访中，患者的步态正常，无痛，膝盖ROM饱满，没有任何局部复发。
■DAM是一种罕见的肿瘤，常被误诊。在这份报告中,我们介绍了一例罕见的良性囊性病变，结果是切除标本的HPE上的DAM。该病变的边缘切除显示良好的结果，直到最后随访12个月才复发。有了这个,我们得出的结论是，在DAM病例中，手术切除应该是金标准。
■一个4岁的男孩被无痛的抱怨，逐步增加,软,非招标，右膝肿胀波动.X线平片显示无钙化的软组织肿胀，MRI显示多部位囊性病变伴多发隔膜。术前诊断为良性囊性病变。通过边缘切除肿瘤进行管理，并进行了DAM的组织学诊断。免疫组化染色显示SMA阳性,CD34和波形蛋白呈局灶性阳性，而desmin和calponin呈阴性。在12个月的随访中，患者的步态正常，无痛，膝盖ROM饱满，没有任何局部复发。
■DAM是一种罕见的肿瘤，常被误诊。在这份报告中,我们介绍了一例罕见的良性囊性病变，结果是切除标本的HPE上的DAM。该病变的边缘切除显示良好的结果，直到最后随访12个月才复发。有了这个,我们得出的结论是，在DAM病例中，手术切除应该是金标准。
