PDF(Pubmed)
Abstract：
BACKGROUND: The benefit of adherence to a plant-based diet concerning colorectal cancer (CRC) has not been investigated among Middle Eastern population. This study aimed to investigate how adherence to a plant-based diet influences the risk of CRC in this understudied population.
METHODS: This case-control study was conducted in the CRC surgery departments of general hospitals in Tehran, Iran. A total of 71 individuals with newly diagnosed CRC (cases) and 142 controls subjects free of cancer and acute illness were concurrently recruited from the same hospital. Dietary information was collected using a semi-quantitative 168-item food frequency questionnaire. Dietary patterns were characterized using the plant-based diet index (PDI), unhealthy plant-based diet index (uPDI) and healthy plant-based diet index (hPDI). Multivariate logistic regression was employed to assess the association between these dietary patterns and the risk of CRC.
RESULTS: After adjusting the potential confounders, the risk of CRC was significantly lower in the highest tertile of hPDI compared to the lowest tertile (odds ratio (OR) = 0.21; 95% confidence interval (CI): 0.07-0.56, representing 79% risk reduction). Conversely, the risk of CRC was significantly higher in the highest tertile of uPDI compared to the lowest tertile (OR = 6.76; 95% CI: 2.41-18.94). PDI was no significant associated with the risk of CRC.
CONCLUSIONS: This study found that higher scores on the hPDI was significantly associated with a decrease risk of CRC, while greater adherence to the uPDI contributed to a significantly increase risk.
METHODS: This case-control study was conducted in the CRC surgery departments of general hospitals in Tehran, Iran. A total of 71 individuals with newly diagnosed CRC (cases) and 142 controls subjects free of cancer and acute illness were concurrently recruited from the same hospital. Dietary information was collected using a semi-quantitative 168-item food frequency questionnaire. Dietary patterns were characterized using the plant-based diet index (PDI), unhealthy plant-based diet index (uPDI) and healthy plant-based diet index (hPDI). Multivariate logistic regression was employed to assess the association between these dietary patterns and the risk of CRC.
RESULTS: After adjusting the potential confounders, the risk of CRC was significantly lower in the highest tertile of hPDI compared to the lowest tertile (odds ratio (OR) = 0.21; 95% confidence interval (CI): 0.07-0.56, representing 79% risk reduction). Conversely, the risk of CRC was significantly higher in the highest tertile of uPDI compared to the lowest tertile (OR = 6.76; 95% CI: 2.41-18.94). PDI was no significant associated with the risk of CRC.
CONCLUSIONS: This study found that higher scores on the hPDI was significantly associated with a decrease risk of CRC, while greater adherence to the uPDI contributed to a significantly increase risk.
摘要：
背景：在中东人群中，尚未研究坚持植物性饮食对结肠直肠癌（CRC）的益处。这项研究旨在调查对植物性饮食的依从性如何影响该未被研究人群的CRC风险。
方法：这项病例对照研究是在德黑兰综合医院的CRC外科部门进行的，伊朗。从同一医院同时招募了总共71名新诊断的CRC（病例）和142名没有癌症和急性疾病的对照受试者。使用半定量168项食物频率问卷收集饮食信息。使用基于植物的饮食指数(PDI)来表征饮食模式，不健康植物性饮食指数（uPDI）和健康植物性饮食指数（hPDI）。采用多变量逻辑回归评估这些饮食模式与CRC风险之间的关联。
结果：调整潜在的混杂因素后，hPDI最高三分位数的CRC风险显著低于最低三分位数(比值比(OR)=0.21;95%置信区间(CI):0.07~0.56,代表风险降低79%).相反，uPDI最高三分位数的CRC风险显著高于最低三分位数(OR=6.76;95%CI:2.41~18.94).PDI与CRC风险无显著相关性。
结论：这项研究发现，较高的hPDI评分与降低CRC风险显著相关，而对uPDI的更高依从性导致风险显著增加.
方法：这项病例对照研究是在德黑兰综合医院的CRC外科部门进行的，伊朗。从同一医院同时招募了总共71名新诊断的CRC（病例）和142名没有癌症和急性疾病的对照受试者。使用半定量168项食物频率问卷收集饮食信息。使用基于植物的饮食指数(PDI)来表征饮食模式，不健康植物性饮食指数（uPDI）和健康植物性饮食指数（hPDI）。采用多变量逻辑回归评估这些饮食模式与CRC风险之间的关联。
结果：调整潜在的混杂因素后，hPDI最高三分位数的CRC风险显著低于最低三分位数(比值比(OR)=0.21;95%置信区间(CI):0.07~0.56,代表风险降低79%).相反，uPDI最高三分位数的CRC风险显著高于最低三分位数(OR=6.76;95%CI:2.41~18.94).PDI与CRC风险无显著相关性。
结论：这项研究发现，较高的hPDI评分与降低CRC风险显著相关，而对uPDI的更高依从性导致风险显著增加.
