PDF(Pubmed)
Abstract：
BACKGROUND: The different symptoms of major depressive disorder (MDD) in adolescents compared to adults suggested there may be differences in the pathophysiology between adolescents and adults with MDD. However, despite the amygdala being considered critical in the pathophysiology, there was limited knowledge about the commonalities and differences in the resting-state functional connectivity (rsFC) of amygdala subregions in MDD patients of different age groups.
METHODS: In the current study, 65 adolescents (46 with MDD and 19 controls) and 91 adults (35 with MDD and 56 controls) were included. A seed-based functional connectivity analysis was performed for each of the amygdala subregions. A 2 × 2 ANOVA was used to analyze the main effect of age, diagnosis, and their interaction on the rsFC of each subregion.
RESULTS: A significant main effect of age was revealed in the rsFC of bilateral centromedial (CM) subregions and right laterobasal (LB) subregion with several brain regions in the limbic system and frontoparietal network. The significant main effect of diagnosis showed MDD patients of different ages showed higher connectivity than controls between the right LB and left middle frontal gyrus (MFG).
CONCLUSIONS: The rsFC of specific amygdala subregions with brain regions in the limbic system and frontoparietal network is affected by age, indicating a distinct amygdala connectivity profile in adolescents. The decreased rsFC between the right LB and the left MFG in adolescents and adults with MDD could serve as a diagnostic biomarker and a target of nonpharmacological treatment for MDD.
METHODS: In the current study, 65 adolescents (46 with MDD and 19 controls) and 91 adults (35 with MDD and 56 controls) were included. A seed-based functional connectivity analysis was performed for each of the amygdala subregions. A 2 × 2 ANOVA was used to analyze the main effect of age, diagnosis, and their interaction on the rsFC of each subregion.
RESULTS: A significant main effect of age was revealed in the rsFC of bilateral centromedial (CM) subregions and right laterobasal (LB) subregion with several brain regions in the limbic system and frontoparietal network. The significant main effect of diagnosis showed MDD patients of different ages showed higher connectivity than controls between the right LB and left middle frontal gyrus (MFG).
CONCLUSIONS: The rsFC of specific amygdala subregions with brain regions in the limbic system and frontoparietal network is affected by age, indicating a distinct amygdala connectivity profile in adolescents. The decreased rsFC between the right LB and the left MFG in adolescents and adults with MDD could serve as a diagnostic biomarker and a target of nonpharmacological treatment for MDD.
摘要：
背景：与成人相比，青少年重度抑郁症（MDD）的症状不同，提示青少年和成人MDD的病理生理学可能存在差异。然而,尽管杏仁核被认为在病理生理学中至关重要，关于不同年龄组MDD患者杏仁核亚区静息态功能连接(rsFC)的共性和差异的认识有限.
方法：在目前的研究中，包括65名青少年（46名MDD和19名对照）和91名成年人（35名MDD和56名对照）。对每个杏仁核亚区进行基于种子的功能连接分析。采用2×2方差分析了年龄的主要影响因素，诊断,以及它们在每个子区域的rsFC上的相互作用。
结果：在双侧中心内侧（CM）亚区域和右鼻侧（LB）亚区域的rsFC中显示出年龄的显着主要影响，在边缘系统和额顶网络中具有多个大脑区域。诊断的显着主要效果显示，不同年龄的MDD患者在右LB和左额中回（MFG）之间的连通性高于对照组。
结论：边缘系统和额顶网络中特定杏仁核亚区域与大脑区域的rsFC受年龄影响，表明青少年的杏仁核连通性特征。青少年和成人MDD患者右LB和左MFG之间rsFC的降低可以作为MDD的诊断生物标志物和非药物治疗的目标。
方法：在目前的研究中，包括65名青少年（46名MDD和19名对照）和91名成年人（35名MDD和56名对照）。对每个杏仁核亚区进行基于种子的功能连接分析。采用2×2方差分析了年龄的主要影响因素，诊断,以及它们在每个子区域的rsFC上的相互作用。
结果：在双侧中心内侧（CM）亚区域和右鼻侧（LB）亚区域的rsFC中显示出年龄的显着主要影响，在边缘系统和额顶网络中具有多个大脑区域。诊断的显着主要效果显示，不同年龄的MDD患者在右LB和左额中回（MFG）之间的连通性高于对照组。
结论：边缘系统和额顶网络中特定杏仁核亚区域与大脑区域的rsFC受年龄影响，表明青少年的杏仁核连通性特征。青少年和成人MDD患者右LB和左MFG之间rsFC的降低可以作为MDD的诊断生物标志物和非药物治疗的目标。
