METHODS: In 2006-8, we assessed height in a cohort of 2074 young adults, aged 16-23 years, in rural Nepal who, as preschoolers (≤ 4 year), were measured at baseline and again 16 months later during a vitamin A supplementation trial in 1989-91. We assessed by linear regression the ability of preschool length (L, measured < 24 mo) or height (Ht, 24-59 mo), at each year of age to predict 16-23 year old height, adjusted for month of young adult age, interval duration (in months), caste, preschool weight-for-height z-score and, in young women, time since menarche, marriage status and pregnancy history.
RESULTS: Young women were a mean of 0.81, 1.11, 0.82, 0.24, 0.44 cm taller (all p < 0.01) and young men, 0.84, 1.18, 0.74, 0.64 and 0.48 cm taller (all p < 0.001) per cm of attained L/Ht at each successive preschool year of age and, overall, were 2.04 and 2.40 cm taller for each unit increase in preschool L/Ht z-score (L/HAZ) (both p < 0.001). Coefficients were generally larger for 16-month follow-up measurements. The percent of young adult height attained by children with normal L/HAZ (>-1) increased from 38-40% mid-infancy to ∼ 69-74% by 6 years of age. By 3-6 years of age heights of stunted children (L/HAZ<-2) were consistently ∼ 4-7% lower in their young adult height versus normal statured children. There was no effect of preschool vitamin A receipt.
CONCLUSIONS: Shorter young children become shorter adults but predictive effects can vary by sex, age assessed, and may be influenced by year or season of measurement.
方法:在2006-8年,我们评估了2074名年轻人的身高,16-23岁,在尼泊尔农村,作为学龄前儿童(≤4岁),在1989-91年的维生素A补充试验中,在基线和16个月后再次测量。我们通过线性回归评估学龄前长度的能力(L,测量<24个月)或高度(Ht,24-59个月),在每个年龄预测16-23岁的身高,调整为年轻成年年龄的月份,间隔持续时间(以月为单位),种姓,学龄前身高体重z评分和,在年轻女性中,月经初潮以来的时间,婚姻状况和怀孕史。
结果:年轻女性平均身高0.81、1.11、0.82、0.24、0.44厘米(均p<0.01),年轻男性,在每个连续的学龄前年龄,每厘米达到的L/Ht高0.84、1.18、0.74、0.64和0.48厘米(所有p<0.001),总的来说,学前L/Htz分数(L/HAZ)每增加一个单位,分别高2.04和2.40厘米(均p<0.001)。对于16个月的随访测量,系数通常较大。正常L/HAZ(>-1)的儿童达到的年轻成人身高百分比从38-40%的婴儿期增加到6岁的69-74%。到3-6岁时,发育迟缓的儿童(L/HAZ<-2)的身高与正常状态的儿童相比,其年轻成人的身高始终要低4-7%。学龄前维生素A的接收没有影响。
结论:矮小的孩子会变成矮小的成年人,但预测效果可能因性别而异,年龄评估,并可能受到测量年份或季节的影响。