Abstract：
OBJECTIVE: To perform tear meniscus particle analysis using anterior segment spectral domain-optical coherence tomography (SD-OCT) and ImageJ software in keratoconus patients.
METHODS: A total of 76 participants (76 eyes) were included in the study. A comprehensive analysis of tear meniscus parameters, including tear meniscus height (TMH), tear meniscus depth (TMD), tear meniscus turbidity (TMT), and percentage of area occupied by particles (PAOP) within the meniscus, was performed in kerataconus patients and healthy controls.
RESULTS: TMT was significantly higher in the keratoconus group, while PAOP was significantly lower (P < 0.05). However, TMH and TMD did not show significant differences between the two groups (P > 0.05). There was a negative correlation observed between TMT and PAOP. In binary logistic regression analysis, TMT and Schirmer score were found to be the most influential factors in predicting keratoconus (odds ratio [OR] = 0.995, P = 0.039 and OR = 1.143, P = 0.021, respectively).
CONCLUSIONS: This study revealed novel findings on analysis of the tear film in keratoconus patients, with higher TMT and lower POAP levels in the keratoconus group compared to the healthy control group.
METHODS: A total of 76 participants (76 eyes) were included in the study. A comprehensive analysis of tear meniscus parameters, including tear meniscus height (TMH), tear meniscus depth (TMD), tear meniscus turbidity (TMT), and percentage of area occupied by particles (PAOP) within the meniscus, was performed in kerataconus patients and healthy controls.
RESULTS: TMT was significantly higher in the keratoconus group, while PAOP was significantly lower (P < 0.05). However, TMH and TMD did not show significant differences between the two groups (P > 0.05). There was a negative correlation observed between TMT and PAOP. In binary logistic regression analysis, TMT and Schirmer score were found to be the most influential factors in predicting keratoconus (odds ratio [OR] = 0.995, P = 0.039 and OR = 1.143, P = 0.021, respectively).
CONCLUSIONS: This study revealed novel findings on analysis of the tear film in keratoconus patients, with higher TMT and lower POAP levels in the keratoconus group compared to the healthy control group.
摘要：
目的：使用前节谱域光学相干断层扫描（SD-OCT）和ImageJ软件对圆锥角膜患者进行泪液半月板颗粒分析。
方法：总共76名参与者（76只眼）被纳入研究。泪液弯月面参数的综合分析,包括撕裂弯月面高度(TMH)，撕裂弯月面深度（TMD），泪液半月板浊度（TMT），以及弯月面内颗粒（PAOP）占据的面积百分比，在角膜炎患者和健康对照中进行。
结果：圆锥角膜组的TMT明显增高，PAOP明显降低(P<0.05)。然而,TMH和TMD两组间差异无统计学意义(P>0.05)。TMT与PAOP呈负相关。在二元逻辑回归分析中，TMT和Schirmer评分是预测圆锥角膜的最重要因素(比值比[OR]=0.995,P=0.039,OR=1.143,P=0.021)。
结论：这项研究揭示了圆锥角膜患者泪膜分析的新发现，与健康对照组相比，圆锥角膜组的TMT水平较高，POAP水平较低。
方法：总共76名参与者（76只眼）被纳入研究。泪液弯月面参数的综合分析,包括撕裂弯月面高度(TMH)，撕裂弯月面深度（TMD），泪液半月板浊度（TMT），以及弯月面内颗粒（PAOP）占据的面积百分比，在角膜炎患者和健康对照中进行。
结果：圆锥角膜组的TMT明显增高，PAOP明显降低(P<0.05)。然而,TMH和TMD两组间差异无统计学意义(P>0.05)。TMT与PAOP呈负相关。在二元逻辑回归分析中，TMT和Schirmer评分是预测圆锥角膜的最重要因素(比值比[OR]=0.995,P=0.039,OR=1.143,P=0.021)。
结论：这项研究揭示了圆锥角膜患者泪膜分析的新发现，与健康对照组相比，圆锥角膜组的TMT水平较高，POAP水平较低。
