PDF(Pubmed)
Abstract：
OBJECTIVE: To investigate whether magnetic resonance imaging (MRI) best detects early malignancy in high-risk women.
METHODS: A retrospective, cross-sectional study, carried out at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, included 419 female breast cancer patients aged 16-84 years (mean age of 49). Data were collected from the radiological department\'s database to compare the MRI, ultrasound (US), and mammography results, with or without tissue biopsy.
RESULTS: In diagnosing benign versus malignant lesions, MRI showed significant agreement with tissue biopsy, with high sensitivity (70%) and specificity (87%); its positive predictive value (PPV) was 92% and negative predictive value (NPV) was 56%. While US has a PPV of 84% and NPV of 63%; with a sensitivity (79%) and specificity (71%). In patients without tissue biopsy, there was little difference between mammography and US compared with MRI results.
CONCLUSIONS: Magnetic resonance imaging is more effective than US and mammography for early detection of BC. It showed high sensitivity in detecting breast lesions and high specificity in characterizing their nature when correlated with pathological results. Ultrasound screening followed by MRI is suggested for undetected or suspected lesions. This will increase the breast lesion detection rate, reduce unneeded tissue biopsies, and enhance the disease\'s survival rate.
METHODS: A retrospective, cross-sectional study, carried out at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, included 419 female breast cancer patients aged 16-84 years (mean age of 49). Data were collected from the radiological department\'s database to compare the MRI, ultrasound (US), and mammography results, with or without tissue biopsy.
RESULTS: In diagnosing benign versus malignant lesions, MRI showed significant agreement with tissue biopsy, with high sensitivity (70%) and specificity (87%); its positive predictive value (PPV) was 92% and negative predictive value (NPV) was 56%. While US has a PPV of 84% and NPV of 63%; with a sensitivity (79%) and specificity (71%). In patients without tissue biopsy, there was little difference between mammography and US compared with MRI results.
CONCLUSIONS: Magnetic resonance imaging is more effective than US and mammography for early detection of BC. It showed high sensitivity in detecting breast lesions and high specificity in characterizing their nature when correlated with pathological results. Ultrasound screening followed by MRI is suggested for undetected or suspected lesions. This will increase the breast lesion detection rate, reduce unneeded tissue biopsies, and enhance the disease\'s survival rate.
摘要：
目的：研究磁共振成像（MRI）是否能最好地检测高危女性的早期恶性肿瘤。
方法：回顾性研究，横断面研究，在阿卜杜勒阿齐兹国王大学医院进行，吉达,沙特阿拉伯,纳入419例女性乳腺癌患者,年龄16~84岁(平均年龄49岁).从放射科的数据库中收集数据以比较MRI，超声（美国），和乳房X线照相术结果,有或没有组织活检。
结果：在诊断良性和恶性病变时，MRI显示与组织活检有显著一致性，具有较高的敏感性（70％）和特异性（87％）；其阳性预测值（PPV）为92％，阴性预测值（NPV）为56％。而US具有84%的PPV和63%的NPV;具有灵敏度(79%)和特异性(71%)。在没有组织活检的患者中，与MRI结果相比,乳房X线照相术和US之间差异不大.
结论：对于早期发现BC，磁共振成像比超声和乳腺X线摄影更有效。当与病理结果相关时，它在检测乳腺病变方面具有很高的敏感性，在表征其性质方面具有很高的特异性。建议对未发现或可疑的病变进行超声筛查，然后进行MRI检查。这将增加乳腺病变的检出率，减少不必要的组织活检，并提高疾病的存活率。
方法：回顾性研究，横断面研究，在阿卜杜勒阿齐兹国王大学医院进行，吉达,沙特阿拉伯,纳入419例女性乳腺癌患者,年龄16~84岁(平均年龄49岁).从放射科的数据库中收集数据以比较MRI，超声（美国），和乳房X线照相术结果,有或没有组织活检。
结果：在诊断良性和恶性病变时，MRI显示与组织活检有显著一致性，具有较高的敏感性（70％）和特异性（87％）；其阳性预测值（PPV）为92％，阴性预测值（NPV）为56％。而US具有84%的PPV和63%的NPV;具有灵敏度(79%)和特异性(71%)。在没有组织活检的患者中，与MRI结果相比,乳房X线照相术和US之间差异不大.
结论：对于早期发现BC，磁共振成像比超声和乳腺X线摄影更有效。当与病理结果相关时，它在检测乳腺病变方面具有很高的敏感性，在表征其性质方面具有很高的特异性。建议对未发现或可疑的病变进行超声筛查，然后进行MRI检查。这将增加乳腺病变的检出率，减少不必要的组织活检，并提高疾病的存活率。
