Abstract:
Aim: Insulin therapy require self-administration of subcutaneous injection leading to painful and inconvenient drug therapy. The aim is to fabricate nanoemulsion (NE) based insulin loaded microneedles with improved bioavailability and patient compliance. Materials & methods: Different ratios of polyvinyl alcohol and polyvinylpyrrolidone as polymers were prepared through micro-molding technique for microneedles. Characterization of were performed using scanning electron microscope, differential scanning calorimetry, Fourier-transform infrared spectroscopy and circular dichroism. Mechanical strength, hygroscopicity and pain perception of these microneedles were also evaluated. In vitro release, permeation and in vivo PK/PD study of NE-based microneedles were conducted. Results: NE-based microneedles of insulin have improved bioavailability and quick response. Conclusion: Microneedles loaded with insulin can be effectively delivered insulin transdermally to treat diabetes with increased convenience and patient compliance.
[Box: see text].
摘要:
目的:胰岛素治疗需要皮下注射的自我给药,导致痛苦和不便的药物治疗。目的是制造具有改善的生物利用度和患者依从性的基于纳米乳液(NE)的胰岛素负载微针。材料和方法:通过微针的微成型技术制备不同比例的聚乙烯醇和聚乙烯吡咯烷酮作为聚合物。使用扫描电子显微镜进行表征,差示扫描量热法,傅里叶变换红外光谱和圆二色性。机械强度,还评估了这些微针的吸湿性和疼痛感知。体外释放,进行了基于NE的微针的渗透和体内PK/PD研究。结果:基于NE的胰岛素微针具有改善的生物利用度和快速的反应。结论:载胰岛素微针可有效经皮给药胰岛素治疗糖尿病,增加了患者治疗的方便性和依从性。
[方框:见正文]。