%0 Journal Article
%T Fabrication and evaluation of nanoemulsion based insulin loaded microneedles for transdermal drug delivery.
%A Ali FR
%A Shoaib MH
%A Ali SA
%A Yousuf RI
%A Ahmed FR
%A Siddiqui F
%A Sarfaraz S
%A Raja R
%J Ther Deliv
%V 0
%N 0
%D 2024 Jul 29
%M 39072401
暂无%R 10.1080/20415990.2024.2377065
%X Aim: Insulin therapy require self-administration of subcutaneous injection leading to painful and inconvenient drug therapy. The aim is to fabricate nanoemulsion (NE) based insulin loaded microneedles with improved bioavailability and patient compliance. Materials & methods: Different ratios of polyvinyl alcohol and polyvinylpyrrolidone as polymers were prepared through micro-molding technique for microneedles. Characterization of were performed using scanning electron microscope, differential scanning calorimetry, Fourier-transform infrared spectroscopy and circular dichroism. Mechanical strength, hygroscopicity and pain perception of these microneedles were also evaluated. In vitro release, permeation and in vivo PK/PD study of NE-based microneedles were conducted. Results: NE-based microneedles of insulin have improved bioavailability and quick response. Conclusion: Microneedles loaded with insulin can be effectively delivered insulin transdermally to treat diabetes with increased convenience and patient compliance.<BR>[Box: see text].