{Reference Type}: Journal Article
{Title}: Fabrication and evaluation of nanoemulsion based insulin loaded microneedles for transdermal drug delivery.
{Author}: Ali FR;Shoaib MH;Ali SA;Yousuf RI;Ahmed FR;Siddiqui F;Sarfaraz S;Raja R;
{Journal}: Ther Deliv
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 29
暂无{DOI}: 10.1080/20415990.2024.2377065
{Abstract}: Aim: Insulin therapy require self-administration of subcutaneous injection leading to painful and inconvenient drug therapy. The aim is to fabricate nanoemulsion (NE) based insulin loaded microneedles with improved bioavailability and patient compliance. Materials & methods: Different ratios of polyvinyl alcohol and polyvinylpyrrolidone as polymers were prepared through micro-molding technique for microneedles. Characterization of were performed using scanning electron microscope, differential scanning calorimetry, Fourier-transform infrared spectroscopy and circular dichroism. Mechanical strength, hygroscopicity and pain perception of these microneedles were also evaluated. In vitro release, permeation and in vivo PK/PD study of NE-based microneedles were conducted. Results: NE-based microneedles of insulin have improved bioavailability and quick response. Conclusion: Microneedles loaded with insulin can be effectively delivered insulin transdermally to treat diabetes with increased convenience and patient compliance.<BR>[Box: see text].